SYNERGIC-2 is the first large Canadian clinical trial using a 12-month home-based personalized multidomain lifestyle intervention to improve cognition in 550 older adults with Mild Cognitive Impairment (MCI), a pre-dementia state. This personalized intervention targets 5 domains, including physical exercise, cognitive training, diet recommendations, sleep interventions, and vascular risk factor management, which are all delivered using a digital platform. This will be compared to the effects of an online educational program. Both interventions are part of the Canadian Dementia Research Strategy.

Studies on early detection of heart disease in young high-risk women with and without PCOS are limited. Polycystic ovary syndrome (PCOS) is the most common hormone-metabolic disorder in women and they are at increased risk of heart disease. Those with PCOS often have infertility, menstrual dysfunction and elevated testosterone levels, and altered metabolism, obesity, diabetes and high blood pressure. We will measure early markers of heart disease at baseline and then at 2yrs follow up including blood fats, heart function and vascular disease in women with and without PCOS with the same age and body weight. The outcomes of this study will help us understand early signs and progression of heart disease in women.

Oxygen (O2) can be both lifesaving and toxic. All ICU patients receiving mechanical ventilation receive O2 therapy. Clinicians are more concerned about a life-threatening lack of O2, termed hypoxia. Accruing evidence now shows that excess O2 exposure, termed hyperoxia, can also cause harm. The adverse effects of hyperoxia may not be immediate. Alberta data show >80% of ICU patients are exposed to hyperoxia. Accordingly, in a clinical trial we are comparing 2 strategies for O2 therapy in ICU patients receiving mechanical ventilation on mortality: usual (liberal) O2 targets vs conservative O2 targets. We are conducting this trial in multiple countries and an to enroll 40,000 critically ill patients.

This registry is for patients who have been diagnosed with an acute aortic dissection/intramural hematoma (also known as a DeBakey I or Stanford type A dissection/intramural hematoma) and have had the Ascyrus Medical Dissection Stent (AMDS) device implanted. The purpose of this registry is to collect additional information of the AMDS following market approval. If the AMDS device, together with conventional surgery is effective, it is believed that this could lead to a cure of the dissection (tear) in the aorta, reduced hospitalizations, and decreased risk of additional aorta surgeries in the chest compared to conventional surgery alone.

The purpose of this study is to find out whether BI 690517 (investigational drug) in combination with empagliflozin helps people with heart failure. Participants are put into 2 groups by chance. Every participant has an equal chance of being in each group. The groups are: - BI 690517 and empagliflozin - Placebo and empagliflozin

The purpose of this study is to develop parental educational tools (that use art and digital platforms) for emergency room settings. The condition that will be reviewed in this study is COVID-19. Using this approach to deliver information to parents and caregivers, we hope to reduce uncertainty and improve knowledge around the illness itself and what families and children can expect. We are looking to interview (1) parents of children who have been diagnosed with COVID-19 or (2) adolescents aged 17-19 who have diagnosed with COVID-19. We will use the interviews to develop and evaluate innovative information tools for parents with COVID-19. These tools will be made widely available using digital and social media platforms.

Adults with idiopathic scoliosis have a reported prevalence of about 2-11%. Some patients experience self-image, function and pain issues which may be amenable to treatment using specific exercises as was recently shown. With our ageing population we also observe a growing number of adults with de novo degenerative scoliosis. This is a spinal misalignment due to spine degeneration. The objective of this study is to compare samples of patients with adults degenerative scoliosis, adult idiopathic scoliosis to matched healthy controls (for age, height and weight). Participants will complete questionnaires and a physical exam to identify which limitations they present that may be amenable to treatment with physical therapy.

In this study we propose to use a drug called colchicine to reduce inflammation. To do this, we propose to ask patients with diabetes mellitus who have had a recent heart attack or a stroke to give blood for markers of inflammation. We will also take pictures of the neck arteries of these patients with a special technique that shows inflammation in the vessel wall. After 6 months treatment with colchicine, we will repeat the blood tests and will take pictures of the arteries again to see if there is less inflammation in the whole body and in the arteries.

We are testing head-mounted computer glasses that integrates the actual visual environment with additional digital images to potentially help patients with: 1) Peripheral vision loss after stroke or visual pathway injury 2) Double vision that does not respond to surgery or prisms 3) Wrinkled retinas (epiretinal membrane) with visual distortion that cannot be fixed by surgery 4) Incessant eye movements (nystagmus) that can cause visual loss, or the perception the visual environment is constantly moving when it is not. Participants will navigate a short obstacle course on level ground with soft objects and read a few paragraphs of English text. The testing can be completed in one or two hospital visits and requires 60-90 minutes.

Chronic kidney disease (CKD) is common, In Canada, approximately 4 million individuals have CKD, and 43,000 have progressed to kidney failure. Most of the 6000 Canadians who develop kidney failure annually start in-center hemodialysis. HD treatments are associated with poor quality of life and adverse outcomes. The HD procedure itself causes repetitive episodes of transient heart muscle injury (called stunning) and is associated with worsening functional status, increased heart failure rates, and sudden cardiac deaths. The study will assess if participation in a 12-week aerobic exercise program during hemodialysis(HD) decreases HD-induced heart muscle injury (cardiac stunning).