Many children with autism spectrum disorder (ASD) have sleep disturbances and problem behaviors, such as aggression. Sleep disturbances may cause irritability or mood concerns that could contribute to problem behaviours. The purpose of this research study is to learn more about the relationships between sleep patterns, Autism symptoms, and problem behaviors in children with ASD. We would like to learn about this through parent questionnaires about behavior and a wrist device that measures sleep and activity level. Parents will fill out questionnaires about their child online. Children will be asked to wear a device on their wrist that measures their sleep and activity level and parents will complete a 7 day sleep diary at the same time. The devices and diary will be sent in the mail.

People with AFib who also have higher body weight can get relief from their symptoms if they lose about 10% of their weight. Research shows that one way to lose a moderate amount of weight and keep it off is by participating in behavioural weight loss treatment (BWLT). BWLT is a group-based therapy program that uses psychology to teach people how to manage their eating better, increase their physical activity, and maintain other healthy behaviours. The purpose of this research study is to test if a BWLT program modified for people with AFib will result in a greater amount of cardiac rehabilitation patients losing 10% of their body weight compared to cardiac rehab patients who receive treatment as usual. We also want to know if people who take part in BWLT experience any changes in AFib symptoms, related health outcomes, and psychological health. If you choose to participate in this study, our team will randomize you to participate in either the experimental or control group. If you're in the experimental group, you'll receive both the regular Total Cardiology rehabilitation program and the BWLT program, consisting of twelve 2-hour group-based weekly sessions that are provided virtually using Zoom. If you are in the control group, you will receive the standard Total Cardiology rehabilitation program. If you are in the experimental group, you will be provided with a Fitbit Aria Scale and Charge 5 fitness tracker that will be yours to keep at the end of the study. All participants will receive a Kardia EKG device to record 2 daily ECG tracings for the duration of the study. If you are interested in participating in this study, please speak with your cardiology healthcare team. Your cardiologist can determine if you would be eligible to participate.

This study investigates how the brain supports paying attention to our own thoughts, independent of the external environment. As part of the study, we will record participants’ brain activity while they do a simple computer task. Brain activity will be recorded using a cap worn on top of the head (scalp electroencephalography). This procedure has minimal to no risks associated with it. The study is being conducted at the University of Calgary. We are currently recruiting individuals with acquired brain damage (due to stroke, traumatic injury, etc.), or individuals who have undergone surgical removal of brain tissue (for e.g., to treat epilepsy). Results from the study will help us understand how we pay attention in daily life, and should help us develop strategies to support individuals who suffer from attentional disorders.

Preliminary research suggests that bipolar disorder and certain types of dementia may be linked. Dementia-related changes are not well understood in bipolar disorder and are difficult to disentangle from the symptoms of bipolar disorder itself. This study is designed to uncover whether certain cognitive tests may be useful as screening tools for early detection of dementia in individuals with bipolar disorder. We are examining this by looking at the relationships between these cognitive tests, dementia biomarkers, and dementia-associated genes in individuals with bipolar disorder. If you choose to participate, you will be asked to: 1) Complete a series of questionnaires and pen-and-paper tasks designed to assess your thinking skills; 2) Have your blood drawn to look for specific biomarkers of neurodegenerative disease.

We are conducting a study to examine the relationship between subjective and objective measures of sleep quality after exercise. We are looking for 60 individuals to volunteer in a sleep study, which includes two weeks of wearing an activity-tracking watch, two nights of an overnight, in-home sleep assessment and three questionnaires regarding your sleep. You will also be asked to perform an aerobic fitness test and a single exercise training session.

We are conducting a study to validate the accuracy of a pulse oximeter that is embedded into an oral appliance. We are looking for up to 40 individuals to volunteer in a controlled desaturation (hypoxia) study, which includes visiting a dentist twice to have an oral appliance made and fitted, then wearing the appliance while you breathe gas mixtures with varying amounts of oxygen.

Organoids are 'mini-organs' generated in the lab to study human biology and disease. In this study, we will harvest cells from the nose to generate organoids to study the function of cystic fibrosis transmembrane conductance regulator (CFTR), the channel that exhibits altered function in patients with cystic fibrosis.

Human rhinovirus is also called the “common cold virus” because it causes at least half of all of the common colds experienced each year. In patients with asthma, getting a rhinovirus infection can also trigger asthma attacks. Current drugs used to treat asthma are not particularly effective during viral infections. Although the symptoms of the common cold are well known, we do not fully understand how the virus causes these symptoms, nor do we really know how it causes asthma attacks. The epithelial cell is the cell that lines the surface of your airways from your nose down to your lungs, and is also the cell type that gets infected by rhinovirus. At present, it is thought that the virus causes symptoms by changing epithelial cell biology in a way that causes airway inflammation. In order to examine how the virus causes inflammation, many earlier studies have used experimental infection with the virus and have measured various markers of inflammation. Cigarette smokers have been reported to be more likely to get colds than non-smokers and asthmatic patients who smoke tend to have more acute attacks and do less well than asthmatics who do not smoke. It is not known why smokers do worse than non-smokers. It is possible that smokers get more inflammation than non-smokers. It is also possible that smokers do not mount a good protective antiviral response to defend against the virus. About 24 healthy volunteers who do not have pre-existing immunity to the virus, and who do not have nasal allergies or asthma will be recruited for this study. Half will be smokers and half will be non- smokers. The purpose of this study is to compare the levels of inflammatory chemicals, and the levels of protective antiviral proteins in the airways of healthy smokers and healthy non-smokers after infection with rhinovirus (the common cold virus).

The goal of this study is to determine whether a specific type of immune cells which we previously identified in mice is also found in humans, and to investigate its possible role in health, during disease and after injury.

The purpose of this study is to learn more about how health problems faced by adults with fetal alcohol spectrum disorder (FASD) differ from those of adults without FASD. The study involves completing questionnaires about your health/mental health, background information, and school/work details. You will also be asked to complete some assessments on an iPad/computer and provide a small blood sample and a small fecal (poop) and salive sample (both collected at home). The study will take approximately 6 hrs of your time (2.5 hrs required in person) and you will be compensated with a gift card for your participation.