Validation of an Oral Appliance Pulse Oximeter

Participation Requirements

• Sex:

  Male, Female, Intersex

• Eligible Ages:

  18 to 50

Participation Criteria

Inclusion Criteria:
To be eligible for the study, you must meet all of the following criteria:
1. Male or female, aged ≥ 18 and < 50 years.
2. In good health with no evidence of medical problems.
3. Ability to provide informed consent and willingness to comply with the study procedures.
4. Ability to undergo controlled hypoxemia to the levels outlined in the desaturation profile.
5. Adequate dentition for an oral appliance.
6. Ability to breathe through the nose comfortably.


Exclusion Criteria:
To be eligible for the study, you may not meet any of the following criteria:
1. Body mass index > 40 kg/m2.
2. Known history of heart, lung, kidney, or liver disease.
3. Diagnosis of asthma or sleep apnea.
4. Diagnosis of diabetes.
5. Presence of a clotting disorder.
6. Presence of hemoglobinopathy or history of anemia that, in the opinion of the PI, makes the individual unsuitable for participation.
7. Current smoker.
8. History of fainting or vasovagal response.
9. History of sensitivity to local anesthesia.
10. Unacceptable collateral circulation based on exam (Allen’s test).
11. Pregnancy or lactation.
12. Resting heart rate > 120 bpm.
13. Systolic BP > 150, diastolic BP > 90.
14. Carboxyhemoglobin level > 3%.
15. Presence of any other condition that, in the opinion of the PI, makes the individual unsuitable for participation.