We are conducting a study to examine the relationship between subjective and objective measures of sleep quality after exercise. We are looking for 60 individuals to volunteer in a sleep study, which includes two weeks of wearing an activity-tracking watch, two nights of an overnight, in-home sleep assessment and three questionnaires regarding your sleep. You will also be asked to perform an aerobic fitness test and a single exercise training session.

We are conducting a study to validate the accuracy of a pulse oximeter that is embedded into an oral appliance. We are looking for up to 40 individuals to volunteer in a controlled desaturation (hypoxia) study, which includes visiting a dentist twice to have an oral appliance made and fitted, then wearing the appliance while you breathe gas mixtures with varying amounts of oxygen.

Organoids are 'mini-organs' generated in the lab to study human biology and disease. In this study, we will harvest cells from the nose to generate organoids to study the function of cystic fibrosis transmembrane conductance regulator (CFTR), the channel that exhibits altered function in patients with cystic fibrosis.

Human rhinovirus is also called the “common cold virus” because it causes at least half of all of the common colds experienced each year. In patients with asthma, getting a rhinovirus infection can also trigger asthma attacks. Current drugs used to treat asthma are not particularly effective during viral infections. Although the symptoms of the common cold are well known, we do not fully understand how the virus causes these symptoms, nor do we really know how it causes asthma attacks. The epithelial cell is the cell that lines the surface of your airways from your nose down to your lungs, and is also the cell type that gets infected by rhinovirus. At present, it is thought that the virus causes symptoms by changing epithelial cell biology in a way that causes airway inflammation. In order to examine how the virus causes inflammation, many earlier studies have used experimental infection with the virus and have measured various markers of inflammation. Cigarette smokers have been reported to be more likely to get colds than non-smokers and asthmatic patients who smoke tend to have more acute attacks and do less well than asthmatics who do not smoke. It is not known why smokers do worse than non-smokers. It is possible that smokers get more inflammation than non-smokers. It is also possible that smokers do not mount a good protective antiviral response to defend against the virus. About 24 healthy volunteers who do not have pre-existing immunity to the virus, and who do not have nasal allergies or asthma will be recruited for this study. Half will be smokers and half will be non- smokers. The purpose of this study is to compare the levels of inflammatory chemicals, and the levels of protective antiviral proteins in the airways of healthy smokers and healthy non-smokers after infection with rhinovirus (the common cold virus).

Some patients gain weight within the first 3 months on psychiatric medications. This weight gain can affect their physical health and result in diabetes and heart disease. Many start taking psychiatric medication in their youth, and prevention strategies early on can help reduce weight gain and other illnesses. Healthy Active Recovery in Mental Health & Obesity; Network for Youth (HARMONY) is a clinical research program focused on practical strategies to help prevent weight gain in youth with mental illness.

Major depressive disorder (MDD) and Inflammatory Bowel Syndrome are common, life-disrupting and highly recurrent illnesses and can co-occur in patients. Unfortunately, 30–40% of patients do not respond to currently available antidepressant drugs or stop taking them because of unpleasant side effects such as obesity or diabetes. Therefore, there is clearly a need to explore alternative treatment options that are more effective and tolerable for individuals with MDD. Here we assess such an alternative, fecal microbiota transfer.

Dementia is an increasingly common condition that can have a significant impact on a patient’s quality of life. Behavioural symptoms of dementia include aggression and agitation, anxiety, depression, hallucinations, and delusions. Out of these symptoms agitation and aggression are particularly distressing to patients and their caregivers. The usual treatment for these symptoms includes behavioral interventions and medications. We have developed a standardized approach to the treatment of these symptoms known as an integrated care pathway (ICP). An ICP is a structured way to help patients toward a better outcome. It has rules for diagnosis and intervention that happen over a specific timeline. It is different from usual care because the steps to diagnose and treat are pre-determined, is based on evidence and is applied the same way across all patients.

The Framework for Research in Emerging Adults (FREA) is an innovative research platform designed to bridge the existing gaps in our understanding of mental health issues affecting individuals aged 16 to 24. This age group is important because of the significant changes they experience during this phase of life, which can have a profound impact on their mental well-being. This study aims to expand the scope of research in this critical area, thereby enhancing the mental health services and therapeutic interventions available to young adults. Furthermore, the study offers an opportunity for participants to actively monitor and track their mental health journey over time, providing valuable insights into their personal growth and development. By joining the FREA Registry for this study, participants are required to periodically complete short questionnaires focused on their mental health experiences and overall well-being. These surveys are designed to be both brief and informative, and continued participation is completely voluntary.

This study will explore the safety and efficacy of Fecal Microbiota Transplantation (FMT) in individuals with OCD. Participants will be given FMT capsules and asked to provide stool, urine, saliva, and blood samples, and will be followed on a weekly basis for a period of 4 months.

Anxiety is the most common childhood disorder, and it can have significant long-term outcomes when not successfully treated. One treatment limitation is poor understanding of what causes anxiety. This study uses a MRI scanner to measure a neurotransmitter system known as the noradrenergic system. The noradrenergic system works in the brain to help with attention, learning, sleep and anxiety. This study will compare this system children with a diagnosis of an anxiety disorder to those without a diagnosis of any anxiety disorder (healthy controls). We will measure this system using MRI three times, spaced out across a year, to understand how this system is changing with time. As well as MRI, we will get measures of stress, cognition and behavior. We will look at how these relate to the noradrenergic system.