The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest
Sudden Cardiac DeathSudden cardiac death (SCD) remains a major cause of mortality within developed nations despite aggressive efforts to reduce its societal burden. Despite extensive clinical and genetic investigations, a subgroup of cardiac arrests remain unexplained, highlighting the potential contribution of additional cardiac conditions that may not be identified with contemporary diagnostic algorithms. The EPS ARREST study aims to evaluate the role of invasive electrophysiology study within this patient population.
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Conditions de participation
-
Sexe:
ALL -
Âges admissibles:
0 and up
Critères de participation
Inclusion Criteria:
1. Unexplained cardiac arrest requiring cardioversion or defibrillation
2. Willing and able to sign informed consent
Exclusion Criteria:
1. Coronary artery disease (stenosis \> 50%) and clinical findings consistent with an ischemic arrest
2. Reduced left ventricular function (left ventricular ejection fraction \< 50%) on echocardiogram or cardiac MRI.
3. Persistent resting QTc \> 460 msec for males and 480 msec for females
4. Resting QTc \< 350 msec
5. Type I Brugada ECG with \>/= 2 mm ST elevation in V1 and/or V2 (Spontaneous or Drug-Induced)
6. Polymorphic or bidirectional ventricular tachycardia observed with exertion on exercise treadmill testing
7. Clinical, electrocardiographic, and/or imaging findings consistent with a diagnosis of arrhythmogenic right ventricular cardiomyopathy
8. Myocarditis
9. Reversible cause of cardiac arrest such as marked hypokalemia (\<2.8 mmol/l) or drug overdose sufficient in severity without other cause to explain the cardiac arrest.
10. Arrhythmic mitral valve prolapse syndrome
11. Documented ventricular fibrillation initiated by a short-coupled premature ventricular contraction
Lieu de l'étude
University of British Columbia
University of British ColumbiaVancouver, British Columbia
Canada
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Andrew D Krahn, MD
Zachary Laksman, MD
Toronto General Hospital
Toronto General HospitalToronto, Ontario
Canada
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Michael H Gollob, MD
British Columbia Children's Hospital
British Columbia Children's HospitalVancouver, British Columbia
Canada
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Shubhayan Sanatani, MD
London Health Sciences Centre
London Health Sciences CentreLondon, Ontario
Canada
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Jason D Roberts, MD MAS
QEII Health Sciences Centre
QEII Health Sciences CentreHalifax, Nova Scotia
Canada
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Ciorsti MacIntyre, MD
Martin Gardner, MD
Montreal Heart Institute
Montreal Heart InstituteMontreal, Quebec
Canada
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Rafik Tadros, MD PhD
University of Calgary
University of CalgaryCalgary, Alberta
Canada
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George Veenhuyzen, MD
Stephen Wilton, MD
Hamilton Health Sciences
Hamilton Health SciencesHamilton, Ontario
Canada
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Jeff Healey, MD
Laval University
Laval UniversityQuebec City, Quebec
Canada
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Christian Steinberg, MD
- Étude parrainée par
- Western University, Canada
- Participants recherchés
- Plus d'informations
- ID de l'étude:
NCT03079414