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The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest

Sudden Cardiac Death

Sudden cardiac death (SCD) remains a major cause of mortality within developed nations despite aggressive efforts to reduce its societal burden. Despite extensive clinical and genetic investigations, a subgroup of cardiac arrests remain unexplained, highlighting the potential contribution of additional cardiac conditions that may not be identified with contemporary diagnostic algorithms. The EPS ARREST study aims to evaluate the role of invasive electrophysiology study within this patient population.

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Conditions de participation

  • Sexe:

    ALL
  • Âges admissibles:

    0 and up

Critères de participation

Inclusion Criteria:

1. Unexplained cardiac arrest requiring cardioversion or defibrillation
2. Willing and able to sign informed consent

Exclusion Criteria:

1. Coronary artery disease (stenosis \> 50%) and clinical findings consistent with an ischemic arrest
2. Reduced left ventricular function (left ventricular ejection fraction \< 50%) on echocardiogram or cardiac MRI.
3. Persistent resting QTc \> 460 msec for males and 480 msec for females
4. Resting QTc \< 350 msec
5. Type I Brugada ECG with \>/= 2 mm ST elevation in V1 and/or V2 (Spontaneous or Drug-Induced)
6. Polymorphic or bidirectional ventricular tachycardia observed with exertion on exercise treadmill testing
7. Clinical, electrocardiographic, and/or imaging findings consistent with a diagnosis of arrhythmogenic right ventricular cardiomyopathy
8. Myocarditis
9. Reversible cause of cardiac arrest such as marked hypokalemia (\<2.8 mmol/l) or drug overdose sufficient in severity without other cause to explain the cardiac arrest.
10. Arrhythmic mitral valve prolapse syndrome
11. Documented ventricular fibrillation initiated by a short-coupled premature ventricular contraction

Lieu de l'étude

University of British Columbia
University of British Columbia
Vancouver, British Columbia
Canada

Contactez l'équipe d'étude

Primary Contact

Andrew D Krahn, MD

Backup Contact

Zachary Laksman, MD

Toronto General Hospital
Toronto General Hospital
Toronto, Ontario
Canada

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Primary Contact

Michael H Gollob, MD

British Columbia Children's Hospital
British Columbia Children's Hospital
Vancouver, British Columbia
Canada

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Primary Contact

Shubhayan Sanatani, MD

London Health Sciences Centre
London Health Sciences Centre
London, Ontario
Canada

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Primary Contact

Jason D Roberts, MD MAS

QEII Health Sciences Centre
QEII Health Sciences Centre
Halifax, Nova Scotia
Canada

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Backup Contact

Ciorsti MacIntyre, MD

Primary Contact

Martin Gardner, MD

Montreal Heart Institute
Montreal Heart Institute
Montreal, Quebec
Canada

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Primary Contact

Rafik Tadros, MD PhD

University of Calgary
University of Calgary
Calgary, Alberta
Canada

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Backup Contact

George Veenhuyzen, MD

Primary Contact

Stephen Wilton, MD

Hamilton Health Sciences
Hamilton Health Sciences
Hamilton, Ontario
Canada

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Primary Contact

Jeff Healey, MD

Laval University
Laval University
Quebec City, Quebec
Canada

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Primary Contact

Christian Steinberg, MD

Étude parrainée par
Western University, Canada
Participants recherchés
Plus d'informations
ID de l'étude: NCT03079414