The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest

Participation Requirements

• Sex:

  ALL

• Eligible Ages:

  0 and up

Participation Criteria

Inclusion Criteria:

1. Unexplained cardiac arrest requiring cardioversion or defibrillation
2. Willing and able to sign informed consent

Exclusion Criteria:

1. Coronary artery disease (stenosis \> 50%) and clinical findings consistent with an ischemic arrest
2. Reduced left ventricular function (left ventricular ejection fraction \< 50%) on echocardiogram or cardiac MRI.
3. Persistent resting QTc \> 460 msec for males and 480 msec for females
4. Resting QTc \< 350 msec
5. Type I Brugada ECG with \>/= 2 mm ST elevation in V1 and/or V2 (Spontaneous or Drug-Induced)
6. Polymorphic or bidirectional ventricular tachycardia observed with exertion on exercise treadmill testing
7. Clinical, electrocardiographic, and/or imaging findings consistent with a diagnosis of arrhythmogenic right ventricular cardiomyopathy
8. Myocarditis
9. Reversible cause of cardiac arrest such as marked hypokalemia (\<2.8 mmol/l) or drug overdose sufficient in severity without other cause to explain the cardiac arrest.
10. Arrhythmic mitral valve prolapse syndrome
11. Documented ventricular fibrillation initiated by a short-coupled premature ventricular contraction