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Treating Postictal Symptoms Using Ibuprofen and Nifedipine

Epilepsy | Epilepsies, Partial

This study will evaluate the effect of ibuprofen or nifedipine on post-seizure hypoperfusion and neurological deficits in patients with epilepsy. One group will receive ibuprofen, another will receive nifedipine, and anther placebo.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    16 and up

Participation Criteria

Inclusion Criteria:

* age \> 16 yrs, frequent seizures (\>1 per week) and cognitive ability sufficient to complete neuropsychological testing.

Exclusion Criteria:

* multiple seizure onset zones, contraindications to CT or MR imaging, any contraindication to ibuprofen or nifedipine, as well as current or recent (\< 2 months) exposure COX-2 inhibitor or calcium channel blocker.

Study Location

Foothills Medical Centre
Foothills Medical Centre
Calgary, Alberta
Canada

Contact Study Team

Primary Contact

Paolo Federico, MD, PhD

[email protected]
(403) 944-4091
South Health Campus
South Health Campus
Calgary, Alberta
Canada

Contact Study Team

Primary Contact

Paolo Federico, MD, PhD

[email protected]
403.944.4091
Study Sponsored By
University of Calgary
Participants Required
More Information
Study ID: NCT03949478