This study includes (one) survey to complete. The purpose of this research study is to understand women’s experiences of their mental health challenges and distresses throughout their lifetime, including: menopause, caregiver burden, grief and loss, common mental health problems, relationship challenges, family difficulties, cancer diagnosis and trauma. We also want to understand women’s experiences and preferences in seeking and obtaining mental health help.

This study seeks to understand the meaning of healthcare experiences for people with problematic alcohol use. A researcher from the University of Calgary is interested in talking to people who self-identify as problematic alcohol drinkers and have had healthcare experiences that they would like to talk about. After a screening meeting to decide if participants are eligible, the researcher will conduct interviews over 1-2 hours with interested participants.

Rare, monogenic forms of systemic inflammatory rheumatic disease are increasingly recognized among patients diagnosed with systemic lupus erythematosus (SLE), autoinflammatory diseases (AIDs), systemic juvenile idiopathic arthritis (sJIA) and vasculitis. These conditions often result from abnormalities within the innate and adaptive immune systems, with a large spectrum of clinical manifestations. Autoinflammatory diseases represent a group of monogenic disorders of which the fever syndromes including familial Mediterranean fever (FMF), tumour necrosis factor-receptor associated periodic syndrome (TRAPS), mevalonate kinase deficiency /hyper-immunoglobulin D syndrome (HIDS), and the cryopyrin associated periodic syndromes (CAPS) are the best-recognized. More recently vasculitis has also been recognized as a component of some monogenic autoinflammatory diseases. Without an accurate diagnosis, affected individuals may not be offered life-changing treatment. Furthermore, an early diagnosis is crucial to enable treatment initiation before irreversible organ damage occurs.

When a brain problem is identified in a baby before it's born (medical term: fetus), doctors try their best to predict how the brain problem will affect the fetus and their family using information from fetal brain pictures (magnetic resonance imaging; MRI). We don't have data to tell us how well doctors predict outcomes based on fetal MRI. Before we can study how predictions and outcomes line up, we have to know what families want to be predicted. We need families with experience with a fetal brain problem to tell us what they wanted or wished to know during the pregnancy.

This study is for children age between 6 months and 17 years who have chronic kidney disease and proteinuria to take part in a 6 months long clinical research study. The primary purpose of this clinical research study is to learn more about an investigational study medicine called finerenone. Individuals will be evaluated to determine their eligibility to participate in this study. Each patient who qualifies will receive the investigational medication, as well as study-related medical exams and study-related laboratory tests, at no cost. Compensation for time and travel may also, be available.

This study aims to improve brain-computer interfaces (BCIs) for children with severe disabilities, such as quadriplegic cerebral palsy (qCP). Currently, BCIs assist individuals in controlling things with their minds, but they are not as effective for children with disabilities who may have difficulty focusing their eyes. The study hypothesizes that by only using brain signals when the children are looking straight ahead, the BCIs may work better. To test this idea, we will involve ten children diagnosed with cerebral palsy and ten children with typical development aged 4 to 16. During the study, they will play a fun game while we measure their brain waves, eye movements, and record a video. We will compare the effectiveness of the BCI when focusing only on moments when the children are looking straight ahead versus not doing so. If our hypothesis proves correct, this improvement could significantly benefit these children, enabling them to perform more tasks independently.

The purpose of this research study is to evaluate an emotion-focused therapy that incorporates elements of mindfulness, distress tolerance, and relationship support. We want to learn if this therapy, called Dialectical Behaviour Therapy (DBT) will help improve quality of life and weight management in youth living with obesity.

Antibiotics are frequently used in Pediatric Intensive Care Units but we don’t know how long to give them to clear infections. Most of what is known about blood tests to diagnose infections is from studies on adult patients. But the immune system in children works somewhat differently than in adults. So we need to study how blood tests can be useful to diagnose severe infections in children. We don’t know how long we should treat critically ill children with antibiotics to make sure that we clear infections. We tend to use antibiotics for a longer period than necessary to ensure infection cure. However, the more we use them, the higher the chance of developing resistant bacteria. We now know that resistant bacteria are becoming a common problem and can make it harder to treat infections in the future The best way to reduce infections caused by resistant bacteria is to reduce unnecessary use of antibiotics. Thus, we are studying blood tests that can help us diagnose infections children who have been admitted to a pediatric intensive care unit and are being treated for a severe bacterial infection to evaluate if they could help us to better define when to stop antibiotics in a safe manner. This would reduce unnecessary antibiotic use and also decrease antibiotic related side effects and resistance. The infection biomarkers we will measure are called C-reactive protein and procalcitonin. There are 4 Canadian children’s hospitals participating in this study. The Alberta Children’s Hospital plans to enroll 100 patients over 4 years

This study is for children aged ≥ 6 months up to 18 years old patients with Tuberous Sclerosis Complex (TSC) or Focal Cortical Dysplasia (FCD) Type II to take part in a 24-week long clinical research study. The primary purpose of this study is to learn more about the safety and effectiveness of an investigational medication for TSC and FCD. Individuals will be evaluated to determine their eligibility to participate in this study. Each patient who qualifies will receive the investigational medication, as well as study-related medical exams and study-related laboratory tests, at no cost. Compensation for time and travel may also be available.

Have you been diagnosed with any of the following? Stevens-Johnson Syndrome (SJS) Recurrent Infectious Mucocutaneous Eruptions (RIME) Mycoplasma pneumoniae Induced Rash & Mucositis (MIRM) Erythema Multiforme (EM) Toxic Epidermal Necrolysis (TEN) Researchers want to understand why people get these severe burn-like skin reactions following infections so that we can better treat them and prevent them from happening to you again. We will collect information from your medical records to identify possible triggers. Since these reactions are rare, we are working with hospitals across the United States and Canada to enroll patients and find answers faster. You will be asked for a sample of saliva (spit) and have the option to give a blood and/or skin sample.