This study aims to evaluate effectiveness in adult migraine patients who have initiated eptinezumab according to the local prescribing information, as well as the treatment patterns and health care resource utilisation (HCRU) in clinical practice.

Our study at the Foothills Hospital aims to understand changes in the immune system and inflammation that may be responsible for cognitive decline after a stroke. We are recruiting control participants for this study. We will collect blood samples, brain imaging, and cognitive testing. The time commitment is 2 hours every year for 4 years.

To help improve the ability to detect dementia before symptoms develop and thereby increase access to early treatment. The study purposes are to improve diagnosis of dementia and help measure effectiveness of future treatments. The specific aims are to identify the earliest features of dementia before symptoms can be detected and to understand how they progress over a period of several years. Without your help, it would be impossible to determine if the values seen in patients with transient ischemic attack are part of the normal variability between individuals or not.

The purpose of this research study is to determine if some people diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) may have another genetic disease that can cause nerve damage, called hereditary TTR amyloidosis (hATTR). hATTR is treated very differently than CIDP, so understanding if hATTR is sometimes incorrectly diagnosed as CIDP is important.

This study seeks to understand the relationship between brain blood flow and the memory symptoms seen in normal aging, mild cognitive impairment, Alzheimer's disease, and a blood vessel condition called cerebral amyloid angiopathy.

Tremor disorders are often misdiagnosed because they can seem similar during check-ups. This can lead to getting the wrong treatment and prognosis. Sometimes, experts can't tell if someone has Parkinson’s disease for sure. This can lead to many wrong guesses. Essential tremor is misdiagnosed 37% of the time, often as Parkinson’s disease. Because there aren't good tools to diagnose, it's even harder to figure out the problem. Regular imaging tests don't help much either.

To evaluate patient-reported improvement with atogepant for the prevention of migraine in the real-world setting.

We aim to improve the lives of children with significant disabilities by making robotic walking available to a group of children who cannot walk on their own. Robotic gait trainers can be an assistive device to increase physical activity levels for these children, which may reduce consequences of inactivity. We will be providing participants with a Trexo robotic gait trainer for 3 months, and will complete assessments before, during, and after the training period, as well as for a time once the training is complete.

The “clot-busting drug” Tissue Plasminogen Activator (tPA) is approved by Health Canada and the U.S. Food and Drug Administration (FDA) for the treatment of ischemic stroke within 3 hours after the stroke symptoms started. In some cases, your doctor may give this drug up to 4.5 hours after the stroke has begun. Stroke patients who arrive at the hospital later than 4.5 hours or who do not get better with tPA may be considered for a procedure to remove the blood clot from the brain called a thrombectomy. The Health Canada and FDA have cleared devices used during the thrombectomy procedure for the treatment of stroke for up to 24 hours after the stroke onset in patients who have a National Institute of Health Stroke Scale (NIHSS) of 6 points or higher. This stroke scale is what is used to determine how bad the stroke is. The higher the score, the worse the stroke symptoms. Currently we do not know if patients with lower stroke scale scores of 5 or less will benefit from the thrombectomy procedure. Therefore, the main goal of this study is to compare patients with a low stroke scale score undergoing the thrombectomy procedure within 8 hours to patient receiving only medical care. The researchers will determine if patients who have had the thrombectomy have less disability and better recovery from the stroke than patients who have standard medical care alone.

This study aims to explore how memory works in people with temporal lobe epilepsy, a condition that causes seizures and is frequently accompanied by memory problems. For some, surgery to remove the part of the brain causing seizures may help, but it does not always work, and memory can get worse afterward. We aim to use magnetic resonance imaging to image the brain participants are completing memory tasks, which will reveal the areas of the brain responsible for memory. This knowledge could help doctors decide which epilepsy patient might benefit from surgery, how to plan surgery to minimize memory loss, and set realistic expectations for patients about their memory after the procedure. As part of the study, patient participants and healthy controls will look at images of faces and scenes as well as words inside a magnetic resonance scanner. Still inside the scanner, participants will have to attempt to remember the images and words you saw after 20 minutes. This way, we will be able to see the areas in the brain responsible for memorizing as well as remembering. We will also ask participants to complete 1 hour of memory tests outside of the scanner.