This study is looking at how shoe sole thickness may affect how you run. If you take part in this study, you will run on a treadmill at two speeds and in three shoes for 18 minutes total. Researchers will collect motion capture data as you run. The speeds are 3.0 m/s (5:30 min/km) and 3.6 m/s (4:40 min/km).

The aim of this study is to see if a 4 week treatment course of brain stimulation (transcranial magnetic stimulation; TMS) can improve attention and behaviour in children with attention deficit/hyperactivity disorder (ADHD). ADHD can have many symptoms with attention being a common problem. Stimulant treatment can improve attention in many children, but some only have partial improvement and others can't tolerate medications. A promising and alternative option for reducing ADHD symptoms is non-invasive brain stimulation. Transcranial magnetic stimulation (TMS) is a form of non-invasive brain stimulation that involves the application of a magnetic field to the skull to change the behaviour and function of underlying brain areas.

The purpose of this clinical research is to look at whether dupilumab works and how safe it is in adults with Chronic Obstructive Pulmonary Disease (COPD). If you choose and are eligible to take part, you will be in the study for a minimum of 26 weeks and up to 40 weeks. The study will consist of 3 parts: 1. Screening Period: 3 weeks period 2. Treatment Period: 24 weeks period 3. Follow-up period: 12 weeks follow-up period

This study is about how to improve care for children when admitted to hospital. We are recruiting patients and caregivers for research interviews. The study focuses on children with medical complexity (CMC). Children with medical complexity have: - complex conditions - chronic conditions - high healthcare use - high caregiving needs and - physical and/or cognitive disabilities. Hospitalization for CMC and their families can be very stressful. These experiences might also contribute to depression, anxiety, and other mental health concerns. Research shows that parents of CMC rate the quality of their child’s hospital care lower than other patient/caregiver groups. This national study aims to design meaningful, comprehensive, and effective health services for CMC in two phases: a Canada-wide survey and a series of focus groups at the Alberta Children's Hospital. Previous research results on CMC caregiver and family experiences shows that some research gaps exist. This study focuses on obtaining feedback from groups who are not well represented. Researchers hope to gather feedback from all kinds of stakeholders.

The purpose of this research study is to evaluate an emotion-focused therapy that incorporates elements of mindfulness, distress tolerance, and relationship support. We want to learn if this therapy, called Dialectical Behaviour Therapy (DBT) will help improve quality of life and weight management in youth living with obesity.

Antibiotics are frequently used in Pediatric Intensive Care Units but we don’t know how long to give them to clear infections. Most of what is known about blood tests to diagnose infections is from studies on adult patients. But the immune system in children works somewhat differently than in adults. So we need to study how blood tests can be useful to diagnose severe infections in children. We don’t know how long we should treat critically ill children with antibiotics to make sure that we clear infections. We tend to use antibiotics for a longer period than necessary to ensure infection cure. However, the more we use them, the higher the chance of developing resistant bacteria. We now know that resistant bacteria are becoming a common problem and can make it harder to treat infections in the future The best way to reduce infections caused by resistant bacteria is to reduce unnecessary use of antibiotics. Thus, we are studying blood tests that can help us diagnose infections children who have been admitted to a pediatric intensive care unit and are being treated for a severe bacterial infection to evaluate if they could help us to better define when to stop antibiotics in a safe manner. This would reduce unnecessary antibiotic use and also decrease antibiotic related side effects and resistance. The infection biomarkers we will measure are called C-reactive protein and procalcitonin. There are 4 Canadian children’s hospitals participating in this study. The Alberta Children’s Hospital plans to enroll 100 patients over 4 years

This study is for children aged ≥ 6 months up to 18 years old patients with Tuberous Sclerosis Complex (TSC) or Focal Cortical Dysplasia (FCD) Type II to take part in a 24-week long clinical research study. The primary purpose of this study is to learn more about the safety and effectiveness of an investigational medication for TSC and FCD. Individuals will be evaluated to determine their eligibility to participate in this study. Each patient who qualifies will receive the investigational medication, as well as study-related medical exams and study-related laboratory tests, at no cost. Compensation for time and travel may also be available.

Have you been diagnosed with any of the following? Stevens-Johnson Syndrome (SJS) Recurrent Infectious Mucocutaneous Eruptions (RIME) Mycoplasma pneumoniae Induced Rash & Mucositis (MIRM) Erythema Multiforme (EM) Toxic Epidermal Necrolysis (TEN) Researchers want to understand why people get these severe burn-like skin reactions following infections so that we can better treat them and prevent them from happening to you again. We will collect information from your medical records to identify possible triggers. Since these reactions are rare, we are working with hospitals across the United States and Canada to enroll patients and find answers faster. You will be asked for a sample of saliva (spit) and have the option to give a blood and/or skin sample.

Potassium is an important mineral body needs to function correctly especially nerves, heart and muscles. Potassium enters in body from the food we eat and from certain medicine. Our kidneys keep potassium at the correct level by flushing the excess out of our body into the urine. If our kidneys are not working properly the potassium level in the blood becomes too high. This is called hyperkalemia, or high potassium. Treatment is required to help body get rid of extra potassium in blood. Sodium zirconium cyclosilicate, SZC (LOKELMA™) is a medicine which is taken orally. It works by taking potassium from our stomach and intestines and removes it. This medicine is not absorbed and is eliminated via stool. This medicine has been shown to be effective and safe in adults through many studies. The purpose of the study is to find out if this new medication called SZC will work and be safe for the treatment of hyperkalaemia in children under 18 years of age. SZC is approved medicine for adults. As such, the information gained from this study will help contribute to better treatments in the future for children living with hyperkalemia.

This study will provide important information about the potential for a dietary fibre supplement to improve glucose control (highs and lows in blood glucose) in patients who have been diagnosed with type 1 diabetes. In this study we will randomize (like a flip of a coin) participants with type 1 diabetes to receive either the prebiotic fibre powder or a non-active ingredient (placebo). The study is 6 months long and you would have to complete some questionnaires and provide stool, blood and urine samples.