If you are interested in participating in research, you can sign up for the Research Registry. The Registry connects young people and families with mental health research studies. Here is how to sign up and what you can expect: 1. Use the link to get into the Research Registry information page. https://is.gd/mhresearch4kids 2. Provide Information - We will collect some information about how to contact you and some information about your mental health. 3. Connect - If there is a study that could be right for you, a research scientist will contact you with details about the study. 4. Choose - It is your choice to participate in any research study, you can say yes or no when a research scientist contacts you. Choose to participate in the studies that are right for you!

Concussion and brain injury are recognized as a major health issue for Canadians. This problem may be especially severe in pediatric populations where brain injury could have life long implications and since children are more likely than adults to have persistent symptoms. We need better tools to quantify concussion. This method, functional near-infrared spectroscopy (fNIRS) detects changes in hemoglobin oxygenation as a marker of brain activity. we will use fNIRS to study functional changes in the brain of subjects following concussion.

Stroke survivors may experience motor learning impairments. Our current assessment tools for understanding motor learning are quite costly and inaccessible to many. This study aims to determine if online motor learning tasks provide similar information to the robotic exoskeleton that we currently use to assess motor learning. In this study you will come to our lab and perform the same task both in the robot and on a desktop computer.

This study will look at using low dose naltrexone (LDN) to reduce fatigue in patients with POTS. Participants will be randomly assigned to either LDN or placebo (cellulose) for a total of 4 months. Participants will not know if they are taking LDN or placebo (blinded study). Participants will take the blinded medication (LDN or placebo) every day. Participants will be provided with a diary to record symptoms. There are two in-person visits at the University of Calgary Autonomic Research Lab. One visit before participants start taking the study medication (LDN or placebo), and one at the end of the 4-month study period. During the in-person study visits we will measure heart rate and blood pressure sitting and standing. We will also draw a blood sample. These visits should take about 1 hour each. Throughout the study, we will send some electronic surveys through our secure servers. These surveys will be completed at home and include questions about autonomic symptoms, fatigue, pain and sleep.

The purpose of this study is to determine if POTS patients perform as well as healthy people on tests of cognition (thinking). The results of this study may help us to better understand if POTS patients' complaints of "brain fog" needs to be studied more carefully. Postural Tachycardia Syndrome (POTS) is a disorder that features an inappropriate increase in heart rate upon standing in addition to chronic symptoms including lightheadedness, dizziness, mental clouding, and palpitations. A common complaint among people with POTS is “brain fog” – a difficulty in concentrating. We are trying to learn more about this “brain fog”. To do this we are are conducting some tests of brain function (on paper and on computer). We are also measuring heart rates and blood pressures while lying down and standing up.

This study aims to help improve the process of starting patients with atrial fibrillation on stroke prevention therapy. To achieve this, patients are placed on blood thinners to reduce their chance of developing stroke. There are five choices of medication to choose from. These drugs have different side effects and benefits. Some of them require monthly testing to ensure optimal functioning and dosing. We have designed a web-based tool to help communicate these information and options in a manner they can relate to using pictures and words. However, we need to test their use in the clinical setting to better understand how it can help us increase patient knowledge and understanding of the disease while stating the importance of use of their blood thinners to minimize their chance of developing stroke.

This is a Phase 2 study to test a single dose of a study drug called REGN7544 in people with postural orthostatic tachycardia syndrome (POTS). The study is double-blind (neither you nor the researchers know if you get the drug or a placebo), randomized (participants are randomly assigned), and placebo-controlled (some people will receive a placebo instead of the study drug). The purpose of the study is to find out how safe, tolerable, and effective the drug is. The study also aims to answer questions like: How does the study drug affect heart rate and blood pressure in people with POTS? What side effects might happen from taking the study drug? How much of the study drug is in the blood at different times? Does the body produce antibodies against the study drug, which could make it less effective or cause side effects? Are there other things we can learn about the study drug and POTS?

The purpose of this research study is to compare and better understand the structural heart differences and the blood flow between POTS patients and healthy individuals. Potential participants will be recruited from the Calgary Autonomic Investigation & Management Clinic at the University of Calgary. We plan to enroll 30 POTS patients and 10 age- and sex-matched healthy controls

This study is comparing two ways of doing an ablation procedure for people with persistent atrial fibrillation. Half of the patients will receive a regular procedure and the other half will have some extra "mapping" done inside the heart for abnormal tissue scientists think may be responsible for AF and those areas would be ablated as well. Patients will not know which kind of procedure they receive. Patients are then followed by study staff every 6 months and wear a 14-day cardiac monitor which will be reviewed with the doctor.

We are studying if increased carbon dioxide (CO2) can lower heart rate and reduces symptoms in patients with Postural Orthostatic Tachycardia Syndrome (POTS). Participants will perform Supine (lying down) to Stand test under different CO2 levels. We will monitor changes in heart rate and symptoms to determine which intervention is the most effective in minimizing symptoms and lowering heart rate.