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Role of Repeat Resection in Recurrent Glioblastoma

Recurrent Glioblastoma | Glioblastoma - Category

Patients with recurrent Glioblastoma (GBM) are commonly presented to surgeons, along with the question of whether or not to re-resect the recurrence. There is no Level 1 evidence to support a role for repeat surgery in this context, but a multitude of observational research suggests that repeat surgery may improve quality survival. Unfortunately, these studies all suffer from selection bias.

The goal of this study is to provide a care trial context to help neurosurgeons manage patients presenting with recurrent GBM, with no additional risks, tests, or interventions than what they would normally encounter in routine care. Secondary goals include a test of the hypothesis that repeat resection can improve median overall survival, and that it can increase the number of days of survival outside of a hospital/nursing/palliative care facility.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

* Age ≥ 18
* Previously histologically confirmed and surgically resected Glioblastoma
* Previous craniotomy for open tumor resection (needle biopsies alone do not count as resection)
* The attending surgeon considers re-operation may improve quality survival

Exclusion Criteria:

* Informed consent not possible

Study Location

University of Alberta Division of Neurosurgery
University of Alberta Division of Neurosurgery
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Sudeshna Bhattacharyna

[email protected]
7804990974
Study Sponsored By
University of Alberta
Participants Required
More Information
Study ID: NCT04838782