This study aims to learn more about the basis of chronic post-traumatic headache following concussion. Chronic post-traumatic headache is in many ways similar to chronic migraine. In this study, we will compare a variety of measures from individuals with chronic post-traumatic headache, individuals with chronic migraine and healthy controls. Participants will complete questionnaires, undergo an MRI scan, and have a blood draw. A better understanding of how chronic post-traumatic headache and chronic migraine differ (and are similar) will inform more effective treatments.

We need thousands of Canadians — both with and without bone and joint conditions —to participate in a number of long-term research studies. The Mobility for Life Project will encompass studies already underway in the institute as well as new initiatives. The information collected will form one of the world’s most comprehensive musculoskeletal health databases, helping researchers identify early indicators of disease, improve diagnosis and target effective treatment. Once enrolled in the project, volunteers will be invited to complete an annual online questionnaire. In addition, participants may be invited to undergo specific imaging, clinical and laboratory testing. These tests will be administered by qualified providers, online or in person at the Centre for Mobility and Joint Health (MoJo) located at the Foothills Campus of the University of Calgary. The results of these tests and evaluations will be available to participants and will be anonymized and kept on a secured database to be used in various ongoing or future studies.

We are seeking healthy adults to participate in a brain imaging (MRI) study. Your participation will contribute to research that aims to explore the feasibility and effectiveness of a neurostimulation technique called Transcranial Ultrasound Stimulation (TUS). The research study aims to help develop non-invasive treatments for various neurological and psychiatric disorders. The time commitment for this study requires five in-person visits of 2-3 hours each at the Seaman Family MR Research Centre at Foothills Hospital and one remote questionnaire.

More research is needed to support youth in the early stages of depression and anxiety symptoms. This project will use brain imaging to help us better understand brain changes in individual children over time, and whether there are brain features that indicate a youth is at increased risk of developing more severe illness.

The University of Calgary is conducting a research study to investigate bone phenotypes and how they change over time using advanced medical imaging techniques. The Bone Imaging Laboratory are looking for healthy, non-fractured volunteers over the age of 18 to participate in this study, and individuals over 50 years who have had a recent (less than 6 months) low trauma fragility fracture.

The goal of this study is to check the safety and effectiveness of blocking small abnormal blood vessels to the knee for patients with knee osteoarthritis. The goal is to decrease pain and increase quality of life.

The research team is trying to determine the relationship between levels of brain chemicals (such as GABA) and development in children. Participation involves a visit to the Alberta Children’s Hospital: * Your child will play some simple computer games * We will take pictures of your child’s brain using magnetic resonance imaging (MRI) while watching a movie of your choice * You will be asked some questions about your child

Children who are born very preterm are at increased risk for problems with attention. Attention skills mature rapidly in young children and are especially important as children start school. In this study we will use brain MRI and measures of attention to find brain differences that may put children born early at greater risk for attention difficulties.

Do you or someone you know suffer from painful and swollen knees? A likely cause is osteoarthritis, a common joint disease that gets worse over time. Osteoarthritis is caused by decreased cushioning between the bones at a joint, causing them to rub together. Although it is quite common, not much is known about what the joint looks like before symptoms are felt or what happens to the bone structure around bone bruises commonly seen in osteoarthritis patients. We're hoping to solve the mystery by evaluating bone changes before surgery using X-ray and MRI images of knees with osteoarthritis.

Our research group, led by Dr. Jeff Dunn, has identified low oxygen levels – a condition known as hypoxia, in the brain of 33% of people with Multiple Sclerosis (MS). We are currently conducting a research study to explore how hypoxia relates to symptoms, brain function, and progression. We apply safe, non-invasive techniques, including near-infrared spectroscopy (NIRS) and electroencephalography (EEG), to measure brain oxygen levels and function. We also conduct MRI scans and collect a blood sample to identify physiological markers, such as inflammation, changes in brain structure and blood flow, and disease progression, as indicated by lesion load and brain atrophy. All techniques used in our study are safe. Participants may choose to take part in one or more components of the study. By comparing results from healthy participants and participants with MS, we aim to better understand how changes in brain oxygen and physiology may be linked to brain function and disease progression. If you are interested in learning more, please fill out the short form below. Our research team will contact you to discuss the study and review eligibility criteria.