Semaglutide (Ozempic/Wegovy®) seems promising at controlling appetite and reducing weight, but how it affects the way our bodies burn calories is still a debate. We are doing a study with 20 people who have obesity and type 2 diabetes. They will use semaglutide once weekly for 6 months, and we will evaluate how their bodies use energy in different situations, such as resting, exercising, eating, and sleeping. We will also explore body composition (e.g., muscle and fat) to determine if semaglutide can prevent the body from slowing down its energy use after weight loss. Our findings may contribute to the development of more personalized treatments, particularly for individuals who do not respond well to conventional treatments.

As CPIN learns from patients, the team will make data and findings available aiming to mobilize knowledge that informs and transforms practice, clinical care and decision making for better and more equitable health outcomes, especially for people with complex and/or unmet needs due to multiple, intersecting determinants affecting their health including linguistic minority status.

This study, called CONVERGE-HF, is looking at a Health Canada approved drug called Vericiguat to see if it can help people who have heart failure and some memory problems. The study will compare Vericiguat to the usual heart failure medications people get. The researchers want to see how well Vericiguat works by looking at brain and heart images, blood tests, physical and mental abilities, quality of life, and any health problems that come up. Participants will take Vericiguat or the usual treatment for approximately 6 months.

We are interested in understanding how the environment you live in, your social circumstances, cultural, and economic conditions can impact your mental well-being and your child’s brain growth. We are especially curious about how these social circumstances might influence your body during pregnancy and your child after birth. We’d like to explore this fascinating connection further. The purpose of this study is to evaluate whether: • Mothers’ social living conditions influence the tiny organisms in the gut of the mother and the child • These tiny organisms in the gut explain how maternal social circumstances influence mother’s mental health and child’s neurodevelopment.

Left bundle branch block (LBBB) is one of the most common complications after patients having the transcatheter aortic valve implantation (TAVI). However, there is no specific guidelines for management of patients with new onset LBBB. The purpose of the study is to determine which clinical management approach has better clinical outcomes to treat a LBBB after TAVI. This study will look at an electrophysiology-based monitoring approach or a follow-up with 30-day transcutaneous cardiac monitor. Participants will be assigned by chance to one of the two methods and then be followed up at 1 month, 3 month, and 12 month by phone or on-site. 

Congenital heart disease (CHD), the most common birth defect, is present in nearly 1% of the population. CHD patients are associated with intense resource utilization and premature death in adulthood. The risk of premature death is linked with reduced exercise capacity, physical activity, and health-related quality of life, all findings noted in youth with CHD. We propose a randomized crossover clinical trial of a home-based high intensity interval training (HIIT) program using a video game-linked bicycle (MedBIKE™) for 10 to 18 year olds with repaired moderate-complex CHD.

A multidisciplinary pain clinic includes researcher-scientists, teaching staff, and patient care related to acute and chronic pain. There is only one university-based outpatient orofacial multidisciplinary pain clinic (OMPC) located in Edmonton, Alberta, Canada, that manages patients with medically complex conditions and includes dental specialists and dentists as part of the expert team. The objective of this study is to explore the characteristics of Edmonton’s OMPC, and to analyze and quantify the delivery, diagnosis, and treatment of orofacial multidisciplinary pain clinic service. Also, to determine a potential association between chronic orofacial pain symptoms and psychological distress.

Our study aims to investigate the health benefits of traditional kefir, a fermented dairy drink, especially in metabolic conditions. Unlike commercial kefir, traditional versions with a mix of bacteria and yeast seem more beneficial. In mice, traditional kefir was better than commercial ones in high-fat/cholesterol conditions. Our pilot trial in humans showed promising results, leading us to explore further in people with high blood glucose. We want to see if traditional kefir improves vascular health and immune outcomes in both females and males over 12 weeks.

SYNERGIC-2 is the first large Canadian clinical trial using a 12-month home-based personalized multidomain lifestyle intervention to improve cognition in 550 older adults with Mild Cognitive Impairment (MCI), a pre-dementia state. This personalized intervention targets 5 domains, including physical exercise, cognitive training, diet recommendations, sleep interventions, and vascular risk factor management, which are all delivered using a digital platform. This will be compared to the effects of an online educational program. Both interventions are part of the Canadian Dementia Research Strategy.

Studies on early detection of heart disease in young high-risk women with and without PCOS are limited. Polycystic ovary syndrome (PCOS) is the most common hormone-metabolic disorder in women and they are at increased risk of heart disease. Those with PCOS often have infertility, menstrual dysfunction and elevated testosterone levels, and altered metabolism, obesity, diabetes and high blood pressure. We will measure early markers of heart disease at baseline and then at 2yrs follow up including blood fats, heart function and vascular disease in women with and without PCOS with the same age and body weight. The outcomes of this study will help us understand early signs and progression of heart disease in women.