Single Dose of Antenatal Corticosteroids for Pregnancies At Risk of Preterm Delivery (SNACS)
Premature Birth | Obstetric Labor, Premature | Pregnancy Complications | Preterm Birth | Complication of PrematurityAntenatal corticosteroids (ACS) reduce the risks of neonatal death and morbidities in preterm infants, such as respiratory distress syndrome.
The standard of care for pregnant people at risk of preterm birth includes 2 doses of Celestone (for a total of 24 mg in Canada, or 22.8 mg in Australia) to accelerate fetal lung maturity.
The investigators plan to conduct a randomized controlled trial to determine whether half the usual dose (12 mg in Canada, or 11.4 mg in Australia) of Celestone is non-inferior to the standard double doses.
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Participation Requirements
-
Sex:
FEMALE -
Eligible Ages:
18 to 55
Participation Criteria
Inclusion Criteria:
1. Pregnant people, aged 18 to 55 years old, at risk of preterm birth with a singleton or twins between 22 weeks and 0 days and \<34 weeks and 6 days gestation who have received only a single dose of Celestone within 24 hours
2. Capable of giving informed, written consent.
Exclusion Criteria:
1. Contraindication to corticosteroids
2. Systemic corticosteroids for medical conditions during the pregnancy (e.g. lupus, severe asthma, Covid, etc).
3. Previous participation in this trial (in a previous pregnancy)
4. Known severe/life-threatening fetal or pregnant patient condition (e.g. fetal congenital/chromosomal abnormality)
5. Demise of one or more fetuses after 14 weeks and 0 days
Study Location
Alberta Health Services; University of Alberta
Alberta Health Services; University of AlbertaEdmonton, Alberta
Canada
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Victoria General Hospital
Victoria General HospitalVictoria, British Columbia
Canada
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The Moncton Hospital, Horizon Health Network
The Moncton Hospital, Horizon Health NetworkMoncton, New Brunswick
Canada
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Queen's University, Kingston General Hospital Health Sciences Centre
Queen's University, Kingston General Hospital Health Sciences CentreKingston, Ontario
Canada
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Sunnybrook Health Sciences Center
Sunnybrook Health Sciences CenterToronto, Ontario
Canada
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Université Laval, Centre de recherche du CHU de Québec
Université Laval, Centre de recherche du CHU de QuébecQuébec City, Quebec
Canada
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University of Calgary, Cumming School of Medicine
University of Calgary, Cumming School of MedicineCalgary, Alberta
Canada
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University of British Columbia; BC Women's Hospital
University of British Columbia; BC Women's HospitalVancouver, British Columbia
Canada
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Dr. Everett Chalmers Regional Hospital
Dr. Everett Chalmers Regional HospitalFredericton, New Brunswick
Canada
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McMaster University
McMaster UniversityHamilton, Ontario
Canada
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Mount Sinai Hospital
Mount Sinai HospitalToronto, Ontario
Canada
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The Centre Hospitalier Universitaire Sainte-Justine, Université de Montréal
The Centre Hospitalier Universitaire Sainte-Justine, Université de MontréalMontréal, Quebec
Canada
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Royal Columbian Hospital
Royal Columbian HospitalNew Westminster, British Columbia
Canada
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University of Manitoba, Health Sciences Centre
University of Manitoba, Health Sciences CentreWinnipeg, Manitoba
Canada
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Memorial University, Eastern Health
Memorial University, Eastern HealthSt. John's, Newfoundland and Labrador
Canada
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Western University; London Health Sciences Centre, Victoria Hospital
Western University; London Health Sciences Centre, Victoria HospitalLondon, Ontario
Canada
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McGill University, McGill University Health Center, Royal Victoria Hospital
McGill University, McGill University Health Center, Royal Victoria HospitalMontréal, Quebec
Canada
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(CIUSSS de l'Estrie-CHUS); Université de Sherbrooke
(CIUSSS de l'Estrie-CHUS); Université de SherbrookeSherbrooke, Quebec
Canada
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Fraser Health, University of British Columbia; Jim Pattison Outpatient Care and Surgery Centre
Fraser Health, University of British Columbia; Jim Pattison Outpatient Care and Surgery CentreSurrey, British Columbia
Canada
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University of Manitoba; St. Boniface General Hospital
University of Manitoba; St. Boniface General HospitalWinnipeg, Manitoba
Canada
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Dalhousie University; Izaak Walton Killam Health
Dalhousie University; Izaak Walton Killam HealthHalifax, Nova Scotia
Canada
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University of Ottawa; The Ottawa Hospital
University of Ottawa; The Ottawa HospitalOttawa, Ontario
Canada
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Sir Mortimer B. Davis Jewish General Hospital; McGill University
Sir Mortimer B. Davis Jewish General Hospital; McGill UniversityMontréal, Quebec
Canada
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University of Saskatchewan, Regina General Hospital
University of Saskatchewan, Regina General HospitalSaskatoon, Saskatchewan
Canada
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- Study Sponsored By
- McMaster University
- Participants Required
- More Information
- Study ID:
NCT05114096