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Optimizing the Management of Staphylococcus Aureus Bacteremia (OPTIMUS-SAB)

Staph Aureus Bacteremia

Staphylococcus aureus bacteremia (SAB) is associated with high morbidity and mortality rates with an incidence disproportionately higher in vulnerable populations. Management according to evidence-based care parameters, in particular Infectious Diseases (ID) consultation, is associated with improved mortality. SAB management is suboptimal in Alberta compared to other jurisdictions. An Alberta-based pilot study confirmed that timely recommendations to optimize SAB care, including ID consultation, was associated with improved adherence to all evidence-based quality-of-care indicators.

Leveraging this pilot work, the investigators aim to implement OPTIMUS-SAB, an enhanced model of the pilot, to optimize and standardize SAB management across Alberta. The implementation study will be a zone-based acute care site stepped wedge design. OPTIMUS-SAB will consist of a centralized SAB care team whom will receive automated notification of all blood cultures positive for S. aureus allowing them to review the patient's medical chart and make preliminary management recommendations according to an evidence-based care bundle.

The investigators will evaluate adherence to evidence-based SAB quality-of-care indicators before and after OPTIMUS-SAB implementation and expect this to improve with a resultant reduction in duration of bacteremia, length of stay, readmission rates, and mortality. In turn, this will translate into cost savings for the health care system.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

* Age greater than 18 years at the time of hospital admission
* Confirmed S. aureus bacteremia by blood culture performed at a laboratory in Alberta, Canada
* Admitted to a designated acute care site in Alberta, Canada

Exclusion Criteria:

* The treating team believes death is imminent or inevitable .
* GCD are C-level within 48 hours of admission.
* The patient is transferred in from an out-of-province acute care center with a pre-existing SAB diagnosis.

Study Location

Athabasca Healthcare Centre
Athabasca Healthcare Centre
Athabasca, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Beaverlodge Municipal Hospital
Beaverlodge Municipal Hospital
Beaverlodge, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Boyle Healthcare Centre
Boyle Healthcare Centre
Boyle, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Peter Lougheed Centre
Peter Lougheed Centre
Calgary, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Canmore General Hospital
Canmore General Hospital
Canmore, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Coaldale Health Centre
Coaldale Health Centre
Coaldale, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Crowsnest Pass Health Centre
Crowsnest Pass Health Centre
Crowsnest Pass, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Drayton Valley Hospital and Care Centre
Drayton Valley Hospital and Care Centre
Drayton Valley, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Grey Nuns Community Hospital
Grey Nuns Community Hospital
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Edson Healthcare Centre
Edson Healthcare Centre
Edson, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Fort Saskatchewan Community Hospital
Fort Saskatchewan Community Hospital
Fort Saskatchewan, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Grande Prairie Regional Hospital
Grande Prairie Regional Hospital
Grande Prairie, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Northwest Health Centre
Northwest Health Centre
High Level, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Innisfail Health Centre
Innisfail Health Centre
Innisfail, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Lacombe Hospital
Lacombe Hospital
Lacombe, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Lloydminster Hospital
Lloydminster Hospital
Lloydminster, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Medicine Hat Regional Hospital
Medicine Hat Regional Hospital
Medicine Hat, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Pincher Creek Health Centre
Pincher Creek Health Centre
Pincher Creek, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Red Deer Regional Hospital Centre
Red Deer Regional Hospital Centre
Red Deer, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Rockyview General Hospital
Rockyview General Hospital
Rockyview, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Sturgeon Community Hospital
Sturgeon Community Hospital
St. Albert, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Myron Thompson Health Centre
Myron Thompson Health Centre
Sundre, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Tofield Health Centre
Tofield Health Centre
Tofield, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Vermilion Health Centre
Vermilion Health Centre
Vermilion, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Wainwright Health Centre
Wainwright Health Centre
Wainwright, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Whitecourt Healthcare Centre
Whitecourt Healthcare Centre
Whitecourt, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Bassano Health Centre
Bassano Health Centre
Bassano, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Bow Island Health Centre
Bow Island Health Centre
Bow Island, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Foothills Medical Centre
Foothills Medical Centre
Calgary, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
St. Mary's Hospital
St. Mary's Hospital
Camrose, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Claresholm General Hospital
Claresholm General Hospital
Claresholm, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Coronation Hospital and Care Centre
Coronation Hospital and Care Centre
Coronation, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Didsbury District Health Services
Didsbury District Health Services
Didsbury, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Glenrose Rehabilitation Hospital
Glenrose Rehabilitation Hospital
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
University of Alberta Hospital
University of Alberta Hospital
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Northern Lights Regional Health Centre
Northern Lights Regional Health Centre
Fort McMurray, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Grande Cache Community Health Complex
Grande Cache Community Health Complex
Grande Cache, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Hardisty Health Centre
Hardisty Health Centre
Hardisty, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Hinton Healthcare Centre
Hinton Healthcare Centre
Hinton, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
William J Cadzow - Lac La Biche Health Care Centre
William J Cadzow - Lac La Biche Health Care Centre
Lac La Biche, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Chinook Regional Hospital
Chinook Regional Hospital
Lethbridge, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Sacred Heart Community Healt
Sacred Heart Community Healt
McLennan, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Peace River Community Health Centre
Peace River Community Health Centre
Peace River, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Raymond Health Centre
Raymond Health Centre
Raymond, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Rocky Mountain House Health Centre
Rocky Mountain House Health Centre
Rocky Mountain House, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Central Peace Health Complex
Central Peace Health Complex
Spirit River, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Strathmore District Health Services
Strathmore District Health Services
Strathmore, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Three Hills Health Centre
Three Hills Health Centre
Three Hills, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
St. Joseph's General Hospital
St. Joseph's General Hospital
Vegreville, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Wabasca/Desmarais Healthcare Centre
Wabasca/Desmarais Healthcare Centre
Wabasca, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Wetaskiwin Hospital
Wetaskiwin Hospital
Wetaskiwin, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Mineral Springs Hospital
Mineral Springs Hospital
Banff, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Oilfields General Hospital
Oilfields General Hospital
Black Diamond, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Brooks Health Centre
Brooks Health Centre
Brooks, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
South Health Campus
South Health Campus
Calgary, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Cardston Health Centre
Cardston Health Centre
Cardston, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Cold Lake Healthcare Centre
Cold Lake Healthcare Centre
Cold Lake, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Daysland Health Centre
Daysland Health Centre
Daysland, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Drumheller Health Centre
Drumheller Health Centre
Drumheller, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Misericordia Community Hospital
Misericordia Community Hospital
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Elk Point Healthcare Centre
Elk Point Healthcare Centre
Elk Point, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
St. Theresa General Hospital
St. Theresa General Hospital
Fort Vermilion, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Grimshaw / Berwyn and District Community Health Centre
Grimshaw / Berwyn and District Community Health Centre
Grimshaw, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
High Prairie Health Complex
High Prairie Health Complex
High Prairie, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Seton - Jasper Healthcare Centre
Seton - Jasper Healthcare Centre
Jasper, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Lamont Health Centre
Lamont Health Centre
Lamont, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Manning Community Health Centre
Manning Community Health Centre
Manning, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Olds Hospital and Care Centre
Olds Hospital and Care Centre
Olds, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Ponoka Hospital
Ponoka Hospital
Ponoka, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Redwater Health Centre
Redwater Health Centre
Redwater, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Slave Lake Healthcare Centre
Slave Lake Healthcare Centre
Slave Lake, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Swan Hills Healthcare Centre
Swan Hills Healthcare Centre
Swan Hills, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
St. Therese - St. Paul Healthcare Centre
St. Therese - St. Paul Healthcare Centre
St. Paul, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Two Hills Health Centre
Two Hills Health Centre
Two Hills, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Viking Health Centre
Viking Health Centre
Viking, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Westlock Healthcare Centre
Westlock Healthcare Centre
Westlock, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Barrhead Healthcare Centre
Barrhead Healthcare Centre
Barrhead, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Bonnyville Healthcare Centre
Bonnyville Healthcare Centre
Bonnyville, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Arthur J.E. Child Comprehensive Cancer Centre
Arthur J.E. Child Comprehensive Cancer Centre
Calgary, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Tom Baker Cancer Centre
Tom Baker Cancer Centre
Calgary, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Our Lady of the Rosary Hospital
Our Lady of the Rosary Hospital
Castor, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Consort Hospital and Care Centre
Consort Hospital and Care Centre
Consort, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Devon General Hospital
Devon General Hospital
Devon, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Cross Cancer Institute
Cross Cancer Institute
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Royal Alexandra Hospital
Royal Alexandra Hospital
Edmonton, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Fairview Health Complex
Fairview Health Complex
Fairview, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Fox Creek Healthcare Centre
Fox Creek Healthcare Centre
Fox Creek, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Hanna Health Centre
Hanna Health Centre
Hanna, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
High River General Hospital
High River General Hospital
High River, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Killam Health Centre
Killam Health Centre
Killam, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Leduc Community Hospital
Leduc Community Hospital
Leduc, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Mayerthorpe Healthcare Centre
Mayerthorpe Healthcare Centre
Mayerthorpe, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Big Country Hospital
Big Country Hospital
Oyen, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen, MD

[email protected]
780-492-5936
Provost Health Centre
Provost Health Centre
Provost, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Rimbey Hospital
Rimbey Hospital
Rimbey, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
George McDougall - Smoky Lake Healthcare Centre
George McDougall - Smoky Lake Healthcare Centre
Smoky Lake, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Stettler Hospital
Stettler Hospital
Stettler, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Taber Health Centre
Taber Health Centre
Taber, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Valleyview Health Centre
Valleyview Health Centre
Valleyview, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Vulcan Community Health Centre
Vulcan Community Health Centre
Vulcan, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Westview Health Centre
Westview Health Centre
Westview, Alberta
Canada

Contact Study Team

Primary Contact

Justin Chen

[email protected]
7804925936
Study Sponsored By
University of Alberta
Participants Required
More Information
Study ID: NCT06338176