FIRE-Diet: Food as an Intervention to Reduce the Effects of Woodsmoke Exposure on Respiratory Health

Participation Requirements

• Sex:

  ALL

• Eligible Ages:

  19 to 40

Participation Criteria

Inclusion Criteria:

* Healthy, and specifically with no respiratory disease
* Not taking any supplements, or willing to abstain from supplement use for 4-weeks prior to study start and the whole duration of the study,
* Must currently consume, on average, less than 2 servings of fish per week and fewer than 5 servings of fruits and vegetables per day based on screening questionnaires.
* Must have a null GSTM1 genotype determined at screening.
* Must be able to provide a sufficient sputum sample during the screening visit.

Exclusion Criteria:

* Pregnant or planning to become pregnant during the study period.
* Health conditions that would pose an unacceptable risk of dietary change, or conditions that are uncontrolled based on principal investigator's judgement.
* Actively attempting to lose weight.
* Frequent wood smoke exposure (e.g. at home or employment).
* Unable to store provided meals and food safely.
* Food allergies/intolerance or food aversion preventing adherence to the intervention diet, or unwillingness/medically unable to adjust diet in line with the intervention.
* Relocation during the study period to an area which will prevent food delivery.
* History of smoking tobacco, marijuana, or and other substance or vaping within the past 6 months, or having smoked the equivalent of 0.5 pack-years ever.
* Body mass index (BMI) \<18.5, as determined during the in-person screening visit.