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Olfactory Outcomes of Dupilumab Treatment for Nasal Polyposis

Chronic Rhinosinusitis With Nasal Polyps | Olfactory Disorder

The study aims to investigate the olfactory TDI score (Threshold, Discrimination, Identification) using the Sniffin' sticks test for patients with chronic rhinosinusitis with nasal polyps (CRSwNP) on dupilumab. Twenty-seven adult patients will be followed up during the treatment with dupilumab on three visits to the Otolaryngology Clinic (Baseline, 3 months and 6 months).

The primary endpoint will be the TDI score. Nasal polyp score, Quality of Olfactory Disorders - negative symptoms (QOD-NS symptom scores), SNOT-22 will be secondary endpoints.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

* Patients older than 18 years old
* Chronic rhinosinusitis with Nasal Polyps
* Olfactory loss
* Clinical indication for treatment with Dupilumab

Exclusion Criteria:

Patients with olfactory loss from other causes such as:

* Sinonasal malignancies
* Trauma
* Idiopathic olfactory loss
* Use of cocaine
* COVID-19 related olfactory loss
* Pregnancy

Lieu de l'étude

St. Joseph's Health Care
St. Joseph's Health Care
London, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Leigh J Sowerby

Étude parrainée par
London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's
Participants recherchés
Plus d'informations
ID de l'étude: NCT04869436