Repetitive Versus Deep Transcranial Magnetic Stimulation for Major Depression

Conditions de participation

• Sexe:

  ALL

• Âges admissibles:

  21 to 70

Critères de participation

Inclusion Criteria:

* Diagnosis of Major Depressive Disorder, at least moderate intensity, single or recurrent episode
* HRSD-17 score of at least 18
* No improvement to at least two adequate courses of antidepressants (based on the ATHF) or were unable to tolerate at least two separate trials of antidepressants of inadequate dose and duration
* On a stable antidepressant regimen for the past four weeks before screening
* Patients with a chronic depressive episode \>2 years and who have previously received ECT or ketamine will be eligible to participate

Exclusion Criteria:

* Having previously received TMS;
* Substance use disorder within the last three months
* Diagnosis of bipolar or psychosis spectrum disorder
* Anxiety or personality disorder that is assessed by a study investigator to be the primary cause and causing greater impairment than MDD
* Concomitant major unstable medical or neurological illness
* Intracranial implant, cardiac pacemaker or implanted medication pump
* Significant laboratory abnormality;
* Active suicidal intent
* Pregnancy
* If participating in psychotherapy, must have been in stable treatment for at least three months before entry into the study, with no anticipation of change
* Currently taking more than the equivalent of 2 mg of lorazepam of a benzodiazepine daily or any dose of an anticonvulsant due to the potential to limit TMS effectiveness