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Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)

Kidney Failure, Chronic | Hyperphosphatemia

During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

1. Age ≥45 years, or Age ≥18 years with diabetes,
2. ESKD on haemodialysis or peritoneal dialysis, for at least 3 months,
3. Currently prescribed at least one phosphate-lowering medication at any dose
4. Able to provide informed consent

Exclusion Criteria:

1. Elective kidney transplantation scheduled,
2. Concomitant major illness / comorbidity that may result in death in the next 6 months in the view of the treating physician,
3. Participation in an interventional study that is likely to affect serum phosphate concentration.

Lieu de l'étude

Foothills Hospital/ U of Calgary
Foothills Hospital/ U of Calgary
Calgary, Alberta
Canada

Contactez l'équipe d'étude

Primary Contact

Louis Girard

[email protected]
Dalhousie University
Dalhousie University
Halifax, Nova Scotia
Canada

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Primary Contact

Karthik Tennankore

[email protected]
Orillia Soldier's Memorial Hospital
Orillia Soldier's Memorial Hospital
Orillia, Ontario
Canada

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Primary Contact

Daniel Tascona, Dr

St Michael's Hospital
St Michael's Hospital
Toronto, Ontario
Canada

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Primary Contact

Ron Wald, Dr

Ron Wald <[email protected]>
416-867-3703
The Charles Lemoyne Hospital
The Charles Lemoyne Hospital
Longueuil, Quebec
Canada

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Primary Contact

Dominic Poirier, Dr

Jewish General Hospital
Jewish General Hospital
Montréal, Quebec
Canada

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Primary Contact

Daniel Blum

[email protected]
Vancouver General Hospital
Vancouver General Hospital
Vancouver, British Columbia
Canada

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Primary Contact

Claire Harris, Dr

Oakville Trafalgar Memorial Hospital
Oakville Trafalgar Memorial Hospital
Oakville, Ontario
Canada

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Primary Contact

Danny Sapir

[email protected]
Scarborough Hospital Network
Scarborough Hospital Network
Scarborough, Ontario
Canada

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Primary Contact

Paul Tam

[email protected]
St. Joseph's Healthcare Toronto
St. Joseph's Healthcare Toronto
Toronto, Ontario
Canada

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Primary Contact

Joanna Sasal

[email protected]
CHUM
CHUM
Montréal, Quebec
Canada

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Primary Contact

William Beaubien

[email protected]
Backup Contact

Marie-Line Caron

[email protected]
Centre Hospitalier Universitaire de Sherbrooke
Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec
Canada

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Primary Contact

Martin Plaisance, Dr

Alberta Health Services
Alberta Health Services
Edmonton, Alberta
Canada

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Primary Contact

David Collister

Queen's University
Queen's University
Kingston, Ontario
Canada

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Primary Contact

Samuel Silver

[email protected]
Lakeridge Health
Lakeridge Health
Oshawa, Ontario
Canada

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Primary Contact

Andrew Steele

[email protected]
University Health Network - University of Toronto
University Health Network - University of Toronto
Toronto, Ontario
Canada

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Primary Contact

Charmaine Lok

[email protected]
McGill University Health Centre
McGill University Health Centre
Montreal, Quebec
Canada

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Primary Contact

Rita Suri

[email protected]
Sacre Coeur Hospital
Sacre Coeur Hospital
Montréal, Quebec
Canada

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Primary Contact

Remi Goupil

[email protected]
St. Paul's Hospital
St. Paul's Hospital
Vancouver, British Columbia
Canada

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Primary Contact

Mercedech Kiaii

[email protected]
London Health Sciences Centre
London Health Sciences Centre
London, Ontario
Canada

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Primary Contact

Matthew Weir

[email protected]
The Ottawa Hospital
The Ottawa Hospital
Ottawa, Ontario
Canada

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Primary Contact

Swapnil Hiremath

[email protected]
St. Joseph's Healthcare Hamilton
St. Joseph's Healthcare Hamilton
Toronto, Ontario
Canada

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Primary Contact

Michael Walsh, Dr

[email protected]
905-522-1155
Hopital Maisonneuve Rosemont
Hopital Maisonneuve Rosemont
Montréal, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Annie-Claire Nadeau-Fredette

[email protected]
CHU de Quebec Universite Laval
CHU de Quebec Universite Laval
Quebec City, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Fabrice Mac-Way

[email protected]
Étude parrainée par
The University of Queensland
Participants recherchés
Plus d'informations
ID de l'étude: NCT03573089