Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
Kidney Failure, Chronic | HyperphosphatemiaDuring end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested. This trial will evaluate whether compared to high levels, lowering blood phosphate levels would reduce death or major events due to heart disease, improve physical health, and be cost-effective.
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Participation Requirements
-
Sex:
ALL -
Eligible Ages:
18 and up
Participation Criteria
Inclusion Criteria:
1. Age ≥45 years, or Age ≥18 years with diabetes,
2. ESKD on haemodialysis or peritoneal dialysis, for at least 3 months,
3. Currently prescribed at least one phosphate-lowering medication at any dose
4. Able to provide informed consent
Exclusion Criteria:
1. Elective kidney transplantation scheduled,
2. Concomitant major illness / comorbidity that may result in death in the next 6 months in the view of the treating physician,
3. Participation in an interventional study that is likely to affect serum phosphate concentration.
Study Location
Foothills Hospital/ U of Calgary
Foothills Hospital/ U of CalgaryCalgary, Alberta
Canada
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Dalhousie University
Dalhousie UniversityHalifax, Nova Scotia
Canada
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Orillia Soldier's Memorial Hospital
Orillia Soldier's Memorial HospitalOrillia, Ontario
Canada
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Daniel Tascona, Dr
St Michael's Hospital
St Michael's HospitalToronto, Ontario
Canada
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The Charles Lemoyne Hospital
The Charles Lemoyne HospitalLongueuil, Quebec
Canada
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Dominic Poirier, Dr
Jewish General Hospital
Jewish General HospitalMontréal, Quebec
Canada
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Vancouver General Hospital
Vancouver General HospitalVancouver, British Columbia
Canada
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Claire Harris, Dr
Oakville Trafalgar Memorial Hospital
Oakville Trafalgar Memorial HospitalOakville, Ontario
Canada
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Scarborough Hospital Network
Scarborough Hospital NetworkScarborough, Ontario
Canada
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St. Joseph's Healthcare Toronto
St. Joseph's Healthcare TorontoToronto, Ontario
Canada
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CHUM
CHUMMontréal, Quebec
Canada
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Centre Hospitalier Universitaire de Sherbrooke
Centre Hospitalier Universitaire de SherbrookeSherbrooke, Quebec
Canada
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Martin Plaisance, Dr
Alberta Health Services
Alberta Health ServicesEdmonton, Alberta
Canada
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David Collister
Queen's University
Queen's UniversityKingston, Ontario
Canada
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Lakeridge Health
Lakeridge HealthOshawa, Ontario
Canada
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University Health Network - University of Toronto
University Health Network - University of TorontoToronto, Ontario
Canada
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McGill University Health Centre
McGill University Health CentreMontreal, Quebec
Canada
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Sacre Coeur Hospital
Sacre Coeur HospitalMontréal, Quebec
Canada
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St. Paul's Hospital
St. Paul's HospitalVancouver, British Columbia
Canada
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London Health Sciences Centre
London Health Sciences CentreLondon, Ontario
Canada
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The Ottawa Hospital
The Ottawa HospitalOttawa, Ontario
Canada
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St. Joseph's Healthcare Hamilton
St. Joseph's Healthcare HamiltonToronto, Ontario
Canada
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Hopital Maisonneuve Rosemont
Hopital Maisonneuve RosemontMontréal, Quebec
Canada
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CHU de Quebec Universite Laval
CHU de Quebec Universite LavalQuebec City, Quebec
Canada
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- Study Sponsored By
- The University of Queensland
- Participants Required
- More Information
- Study ID:
NCT03573089