"SCRIBBLE" Spinal Cord Injury Blood Biomarker Longitudinal Evaluation

Participation Requirements

• Sex:

  ALL

• Eligible Ages:

  19 and up

Participation Criteria

Inclusion Criteria

SCI Participants. Patients who suffer a traumatic spinal cord injury who meet the following inclusion criteria are eligible for admission into the study as "SCI participants":

* Male or Female ≥ 19 years of age
* Blunt (non-penetrating) traumatic spinal cord injury
* Baseline neurologic impairment deemed "complete"(AIS A) or "incomplete" (AIS B, C, D)
* Bony spinal level involvement between C0 and L1 inclusive
* Ability to have initial blood sample drawn within 24 hours of injury
* Have either an arterial line, central line, or intravenous line for collecting blood samples
* Able and willing to provide informed consent

Non-SCI Spine Trauma Control Participants. Patients who suffer a fracture or dislocation of their spinal column without neurologic injury who meet the following inclusion criteria are eligible for admission into the study as "Non-SCI Spine Trauma Control Participants":

* Male or Female ≥ 19 years of age
* Traumatic spinal fracture between C0 and L1 without spinal cord injury
* Collection of initial blood sample within 24 hours of injury
* Have either an arterial line, central line, or intravenous line for collecting blood samples
* Able and willing to provide informed consent

Exclusion Criteria

Patients who fulfill any of the following criteria are not eligible for admission into the study:

* Penetrating spinal cord injury (e.g. gunshot, stab)
* Spinal cord injury with sensory deficit only (i.e. no motor deficit)
* Spinal injury below L1
* Isolated radiculopathy without fracture
* Isolated cauda equina injury
* Pre-existing thromboembolic disease or coagulopathy (disorders related to blood clotting), such as haemophilia or von Willebrand's disease
* Have any other medical condition that in the investigator's opinion would render the study procedures dangerous or impair their ability to receive treatment