Tryptophan Requirements During Pregnancy
PregnancyPregnancy is an important period of life where there is an increased need for nutrients including protein and amino acids from food. The current protein and amino acids dietary recommendations were all established using older methods done in adult men. Then protein and amino acids requirements for all stages of pregnancy were calculated without accounting for changing demands in each trimester. Therefore, another more precise method is needed to better understand how much amino acids (in this study tryptophan) women need during pregnancy.
In the current study, the investigators are going to apply the Indicator Amino Acid Oxidation (IAAO) method to measure the dietary tryptophan needs in a healthy pregnancy. This method is a noninvasive, quick, and reliable technique that uses a stable isotope-labeled amino acid. The stable isotope tracer is a labeled amino acid, which is colorless, odorless, tasteless, and completely safe; they are present in the air, water and food. Amino acids are mostly made of Carbon-12 (12C), whereas the isotope tracer contains Carbon-13 (13C). The tracer can be detected in breath and urine samples with special equipment because it looks different than the rest of the amino acids in the body. In Elango lab, the investigators have done similar studies, using the same technique in children, nonpregnant women and pregnant women. This will allow us to measure tryptophan needs in pregnancy.
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Conditions de participation
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Sexe:
FEMALE -
Âges admissibles:
20 to 40
Critères de participation
Inclusion Criteria:
* Cis-gendered pregnant woman.
* 20-40 years of age.
* Pregnant with a single child.
* Between 11-20 weeks of gestation or 31-40 weeks of gestation.
* Free of chronic diseases/acute diseases and have a full range of physical mobility.
Exclusion Criteria:
* Women who are not pregnant.
* Women who are pregnant with more than one child (this changes amino acid demands) or were pregnant in the 6 months before the current pregnancy.
* Women with a history of spontaneous abortion (within the last 6 months) or preterm birth.
* Women not in good health or have a metabolic, cardiovascular, neurological, genetic, or immune disorder, including gestational diabetes, preeclampsia, pregnancy-related anemia, or pregnancy-related jaundice.
* Claustrophobic women (a clear hood will be placed, which can easily be removed, over the participants head for approximately 20 min to measure energy expenditure).
* Women who are substance dependent (i.e., alcohol, tobacco, illicit drugs).
* Women who have severe nausea/vomiting throughout their pregnancy.
* Women under the age of 20 years and over the age of 40 years.
* Women who have lost weight (approximately 1.5kg or more) during their current pregnancy.
* Women with a pre-pregnancy Body Mass Index (BMI) under 19 or over 28 〖kg/m〗\^2.
Lieu de l'étude
BC Children's Hospital Research Institute, University of British Columbia
BC Children's Hospital Research Institute, University of British ColumbiaVancouver, British Columbia
Canada
Contactez l'équipe d'étude
- Étude parrainée par
- University of British Columbia
- Participants recherchés
- Plus d'informations
- ID de l'étude:
NCT06519071