The Impact of Ketone Monoester Intake on Post-exercise Hormonal Responses After Resistance Exercise in Young Males
Ketosis | Resistance Exercise | Testing Effect of Intervention | Ketone Body | Blood HormonesThis study investigates how orally ingested exogenous ketone monoester supplements affect circulating hormone concentrations in healthy young adult males after a single session of resistance exercise. Resistance exercise is known to stimulate an acute increase in the circulating concentration of various hormones that are involved in the regulation of muscle mass, including testosterone, growth hormone (GH), and insulin-like growth factor-1 (IGF-1).
Recently, there has been growing interest in how nutritional supplements impact these natural hormone responses at rest. One such intervention is the oral ingestion of exogenous ketone body supplements. Ketone bodies (i.e., β-hydroxybutyrate (β-HB), acetoacetate (AcAc), and acetone) are naturally occurring compounds that are normally produced by the body during prolonged fasting/starvation, or in response to a "ketogenic" diet (a diet very high in fat and very low in carbohydrates). These ketone body supplements taken in the form of a ketone monoester can quickly raise blood ketone levels without needing to change your diet.
Recent research has shown that the ingestion of exogenous ketone supplements or following a 'ketogenic diet' can alter the concentration of certain hormones measured in blood samples at rest. However, the effects of ketone monoester intake on the exercise-induced elevation in circulating hormones is yet to be explored.
Therefore, the purpose of this study is to examine how elevated β-HB, induced via the ingestion of the ketone monoester (R)-3-hydroxybutyl-(R)-3-hydroxybutyrate, affects blood concentrations of various anabolic hormones, during post-exercise recovery in healthy young adult males, compared to a placebo drink (flavoured water).
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Conditions de participation
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Sexe:
MALE -
Âges admissibles:
18 to 40
Critères de participation
Inclusion Criteria:
* Healthy adult male participants who are 18-40 years of age (inclusive).
* BMI \>18.5 and \<30.0 kg/m2
* Recreationally active (at least of 150 minutes of activity/week).
* Has maintained stable use of medication and supplements (which are not limited by the exclusion criteria), stable dietary and lifestyle habits, and stable body weight, for the last 3 months prior to screening and agree to maintain them throughout the study.
* Be willing to entirely avoid alcohol consumption 48 hours prior to the test days.
* Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, be able to understand and read the questionnaires, and carry out all study-related procedures.
Exclusion Criteria:
* Individuals with metabolic disorders including: Type I or Type II diabetes.
* Individuals with a history of thrombosis / cardiovascular disease, endocrine disorders
* Individuals with knee injuries (i.e., ACL injuries).
* Individuals with a positive medical history of unstable thyroid disease (i.e., hypothyroidism, hyperthyroidism, hyperparathyroidism, and hypoparathyroidism) and immune disorders.
* Individuals who have used tobacco products within the last 6 months.
* Chronic usage of medications known to modulate hormone levels (i.e. corticosteroids and hormone replacement therapy (HRT)) in the last 6 months.
* Current use of ketone supplements or adherence to a ketogenic diet.
* Formal or regular weightlifting activity within the last year.
Lieu de l'étude
McGill University
McGill UniversityMontreal, Quebec
Canada
Contactez l'équipe d'étude
Tyler Churchward-Venne, PhD
- Étude parrainée par
- McGill University
- Participants recherchés
- Plus d'informations
- ID de l'étude:
NCT06683547