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Beta blocker deprescription following coronary artery bypass graft surgery: feasibility and safety pilot (BEEFBURGER Trial)

Atrial Fibrillation | Heart Failure | Atrial Flutter | Coronary Artery Bypass Grafting | CABG | Afib |...

Patients who have undergone an isolated and uncomplicated coronary artery bypass surgery (also known as CABG where blood flow is redirected around blocked or partially blocked arteries of the heart) and are on a medication called a beta-blocker may participate in this study.

Beta-blockers are traditionally used for all patients post-CABG surgery, but we do not completely understand if they are needed long-term after uncomplicated CABG surgery, especially in patients who do not have weakened heart muscles or arrhythmias.

We are doing this study to find out if beta-blockers are necessary for uncomplicated post-CABG surgery patients and if it is safe to de-prescribe them, after bypass surgery, in patients who have normal heart function.

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Conditions de participation

  • Sexe:

    Any

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:
1. Age ≥ 18 years treated with index isolated CABG
2. Able to consent to study
3. On beta blocker therapy at the 6-12 week visit
4. LV systolic function ( ≥45% assessed within 6 months of CABG date)
5. Sinus rhythm or post op atrial fibrillation lasting < 24 hours
Exclusion Criteria:
1. Prior CABG procedure
2. Prior heart failure with reduced ejection fraction (LVEF <45%)
3. Pre-op atrial fibrillation or flutter
4. Pre-op stroke due to atrial fibrillation or flutter
5. Atrial fibrillation at 6-12 weeks post-op follow-up
6. Anti-arrhythmic drug to maintain sinus rhythm or need for an oral anticoagulant
7. Peri-CABG stroke
8. Unable to follow-up

Lieu de l'étude

Royal University Hospital
Royal University Hospital
Saskatoon, Saskatchewan
Canada

Contactez l'équipe d'étude

Primary Contact

Jay Shavadia, MD

[email protected]
3069862260
University of Alberta
University of Alberta
Edmonton, Alberta
Canada

Contactez l'équipe d'étude

Primary Contact

Nasim Boroumand

[email protected]
780-407-2667
Primary Contact

Tracy Jordan

[email protected]
780-407-1470
Étude parrainée par
University of Saskatchewan
Participants recherchés
Plus d'informations
ID de l'étude: NCT04788186