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Using Exercise and Electrical Brain Stimulation to Improve Memory in Dementia

Alzheimer Disease | Mild Cognitive Impairment

Mild cognitive impairment and Alzheimer's disease are conditions that involve memory difficulties. Transcranial direct current stimulation is a type of brain stimulation. It may help improve these memory difficulties. However, it works better on active brain areas. This study looks at if combining exercise and applying current to important parts of the brain can help improve memory in people with Mild Cognitive Impairment or Alzheimer's disease.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    50 and up

Critères de participation

Inclusion Criteria:

* Males or females ≥50 years of age
* DSM-5 criteria for major or mild neurocognitive disorder due to AD or mixed AD/vascular disease
* Mild severity of impairment (standardized Mini-Mental State Examination (MMSE) score ≥19)
* Read and communicate in English

Exclusion Criteria:

* Change in cognitive enhancing medications (ChEIs and/or memantine) less than 3 months prior to study screen
* Change in anticonvulsants or psychotropic medications less than 1 month prior to study screen
* Currently taking benzodiazepines
* Presence of metal implants that would preclude safe use of tDCS (e.g. pace-maker)
* Significant neurological condition (e.g. epilepsy, Parkinson's disease, multiple sclerosis)
* Current psychiatric disorders (e.g. schizophrenia, bipolar disorder, depression, psychosis) or current substance use disorder
* Medical contraindications to increasing activity level according to the Canadian Society of Exercise Physiology Questionnaire

Lieu de l'étude

Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences Centre
Toronto, Ontario
Canada

Contactez l'équipe d'étude

Étude parrainée par
Sunnybrook Health Sciences Centre
Participants recherchés
Plus d'informations
ID de l'étude: NCT03670615