Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery
Cardiac Surgery | Postoperative | Heart | DisorderTRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on cardiopulmonary bypass, using a superiority trial design.
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Participation Requirements
-
Sex:
ALL -
Eligible Ages:
18 to 65
Participation Criteria
Inclusion Criteria:
1. ≥18 and ≤65 years of age
2. Planned cardiac surgery using cardiopulmonary bypass
3. Informed consent obtained
4. Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more
Exclusion Criteria:
1. Patients who refuse participation
2. Patients who are unable to receive or who refuse blood products
3. Patients who are involved in a preoperative autologous pre-donation program
4. Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device
5. Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization for women of childbearing potential)
Study Location
University of Alberta Hospital
University of Alberta HospitalEdmonton, Alberta
Canada
Contact Study Team
Wing Lam, MD
Hamilton Health Sciences Centre / Hamilton General Hospital
Hamilton Health Sciences Centre / Hamilton General HospitalHamilton, Ontario
Canada
Contact Study Team
Richard Whitlock
St. Michael's Hospital, Unity Health Toronto
St. Michael's Hospital, Unity Health TorontoToronto, Ontario
Canada
Contact Study Team
David Mazer, MD
Centre hospitalier de l'Université de Montréal
Centre hospitalier de l'Université de MontréalMontréal, Quebec
Canada
Contact Study Team
François Carrier
Saint John Regional Hospitall
Saint John Regional HospitallSaint John, New Brunswick
Canada
Contact Study Team
Craig Brown
Sunnybrook Health Sciences Center
Sunnybrook Health Sciences CenterToronto, Ontario
Canada
Contact Study Team
Stephen Fremes, MD
Jewish General Hospital
Jewish General HospitalMontreal, Quebec
Canada
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Matthew Cameron, MD
Interior Health Kelowna General Hospital
Interior Health Kelowna General HospitalKelowna, British Columbia
Canada
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Nick Kuzak
Kingston Health Sciences Centre
Kingston Health Sciences CentreKingston, Ontario
Canada
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Toronto General Hospital
Toronto General HospitalToronto, Ontario
Canada
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Matteo Parotto, MD
Hôpital Sacré-Cœur de Montréal
Hôpital Sacré-Cœur de MontréalMontréal, Quebec
Canada
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Hugues Jeanmart, MD
Vancouver General Hospital
Vancouver General HospitalVancouver, British Columbia
Canada
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Darren Mullane, MD
Health Sciences North Research Institute
Health Sciences North Research InstituteSudbury, Ontario
Canada
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Eugene Leshchyshyn, MD
Montreal Heart Institute
Montreal Heart InstituteMontreal, Quebec
Canada
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Antoine Rochon, MD
Institut universitaire de cardiologie et de pneumology de Québec - université Laval (IUCPQ-UL)
Institut universitaire de cardiologie et de pneumology de Québec - université Laval (IUCPQ-UL)Québec, Quebec
Canada
Contact Study Team
Étienne J Couture
- Study Sponsored By
- Unity Health Toronto
- Participants Required
- More Information
- Study ID:
NCT04754022