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Canadian-Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease

Coronary Artery Disease | Kidney Transplant | Screening

Patients on the waiting list for kidney transplantation are at risk for coronary artery disease (CAD). Current standard of care strategy is that patients without any symptoms will have routine test to determine if they have heart diseases. However, this current screening strategy is not evidence based, has substantial known and potential harms, and is very costly. The purpose of the study is designed to determine which strategy (regular screening or screening only in the presence of symptoms) is more effective in preventing heart attacks in kidney transplant candidates.

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Participation Requirements

  • Sex:

    Any

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:
1. adults aged 18 years of age or older;
2. in dialysis, currently active or being assessed on kidney transplant waiting list
3. expected to do the routine screening test for Coronary Artery Disease
4. able to five consent
5. will not have kidney transplant within 12 months from date of enrolment.
Exclusion Criteria:
1) patients with signs or symptoms suggestive of uncontrolled cardiac disease such as unstable coronary syndromes, decompensated heart failure, uncontrolled arrhythmia, and severe valvular heart disease;
2) patients on-hold for transplantation due to a medical problem;
3) patients with other solid organ transplants;
4) multi-organ (more than one organ) transplant candidates ;
5) patients with planned living donor transplant.

Study Location

University of Alberta
University of Alberta
Edmonton, Alberta
Canada

Contact Study Team

Study Sponsored By
University of Alberta
Participants Required
More Information
Study ID: Pro00103344