An Innovative Master Platform for Clinical Trials in Mood Disorders
Mood Disorders | Depressive Disorder | Bipolar and Related DisordersMood disorders such as depression and bipolar disorder affect over 350 million people around the world. While several effective treatments exist, it is often difficult to match the right treatment to an individual person. Repeated efforts to find the right treatment contribute to poor functioning, low quality of life, and prolongs the time it takes to get well. Most areas of medicine are able to use 'biomarkers' or clinical tests, blood tests, or imaging to help diagnose and treat illness. The search for biomarkers in mood disorders is advancing, but one roadblock to progress is the lack of large, standardized studies of mood disorders that are needed to accurately identify biomarkers. The aim of the ENABLE platform is to provide the Canadian neuroscience community a standardized way of collecting biomarker data from individuals with a range of mood disorders symptoms. In addition, this 'master clinical trial platform' framework will provide a pool of participants who can be recruited into biomarker-based clinical trials.
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Participation Requirements
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Sex:
ALL -
Eligible Ages:
16 and up
Participation Criteria
Inclusion Criteria
Patients:
1. 16 years of age or older.
2. Meet criteria for bipolar or depressive disorders as defined by DSM-5.
3. Fluency in English, sufficient to complete the interviews and self-report questionnaires.
Inclusion Criteria
Healthy Comparison (HC) Participants:
1. 16 years of age or older.
2. No history of psychiatric disorders (according to DSM-5) or significant unstable medical conditions.
3. Fluency in English, sufficient to complete the interviews and self-report questionnaires.
Study Location
University of British Columbia
University of British ColumbiaVancouver, British Columbia
Canada
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Raymond W Lam, MD
University of Ottawa
University of OttawaOttawa, Ontario
Canada
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Pierre Blier, MD, PhD
University of Calgary
University of CalgaryCalgary, Alberta
Canada
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Valerie H Taylor, MD, PhD
Queen's University
Queen's UniversityKingston, Ontario
Canada
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Roumen Milev, MD, PhD
McMaster University
McMaster UniversityHamilton, Ontario
Canada
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Benicio N Frey, MD, PhD
Centre for Addiction and Mental Health
Centre for Addiction and Mental HealthToronto, Ontario
Canada
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Lena Quilty, PhD
Nova Scotia Health Authority
Nova Scotia Health AuthorityHalifax, Nova Scotia
Canada
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Rudolf Uher, MD
University Health Network
University Health NetworkToronto, Ontario
Canada
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Joshua Rosenblat, MD
- Study Sponsored By
- St. Joseph's Healthcare Hamilton
- Participants Required
- More Information
- Study ID:
NCT06408012