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SONOthrombolysis in Patients With an ST-segment Elevation Myocardial Infarction With fibrinoLYSIS (SONOSTEMI-LYSIS) Trial

ST Elevation Myocardial Infarction

This study will assess the safety and feasibility of sonothrombolysis in the acute management of STEMI undergoing reperfusion therapy with systemic fibrinolysis as part of a pharmacoinvasive approach

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

* Patients presenting with STEMI within 6 hours of symptom onset and:

1. Are expected to receive reperfusion therapy with fibrinolysis
2. Have a high-risk STEMI ECG as defined as:

* \>2mm ST-segment elevation in 2 anterior or lateral leads; or
* \>2mm ST-segment elevation in 2 inferior leads coupled with ST-segment depression in 2 contiguous anterior leads for a total ST-segment deviation of \>4mm
3. Age \>30 years
4. Adequate apical and/or parasternal images by echocardiography

Exclusion Criteria:

* 1. Isolated inferior STEMI without anterior ST-segment depression 2. Previous coronary bypass surgery 3. Cardiogenic shock 4. Known or suspected hypersensitivity to ultrasound contrast agent used for the study 5. Life expectancy of less than two months or terminally ill 6. Known bleeding diathesis or contraindication to glycoprotein 2b/3a inhibitors, anticoagulants, or aspirin 7. Known large right to left intracardiac shunts 8. Patient received another investigational medication or treatment within 30 days prior to presentation with STEMI

Lieu de l'étude

University of Alberta
University of Alberta
Edmonton, Alberta
Canada

Contactez l'équipe d'étude

Primary Contact

Kevin Bainey, MD

[email protected]
780-407-2176
Étude parrainée par
University of Alberta
Participants recherchés
Plus d'informations
ID de l'étude: NCT04217304