Senescent Endometrial Cells in Patients with Thin Endometrial Lining
Asherman's Syndrome | Cell Senescence | Thin Endometrial LiningThe goal of this observational study is to determine if thin endometrial lining that is unresponsive to estrogen might be associated with the presence of senescent cells in patients following long-term use of oral contraceptives. The main question it aims to answer is:
Are there any senescent cells present in thin endometrial lining?
During the luteal phase of the cycle, participants will will undergo:
* Gynecologic US to measure the endometrial lining thickness and pattern.
* Endometrial biopsy with Pipelle catheter
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Participation Requirements
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Sex:
FEMALE -
Eligible Ages:
18 to 39
Participation Criteria
Inclusion Criteria:
* Age 18-39
* BMI - up to 35
* Thin endometrium after OCP use
* Asherman's syndrome
* Women already undergoing endometrial biopsy for infertility testing (eg. EMMA testing)
* Women with archived endometrial biopsy samples
Exclusion Criteria:
* Women with systemic disease (Rheumatic disease, DM)
* Women with coagulopathies
* Women with active pelvic inflammatory process
* Uterine anomalies
* Pregnant women
* Any hormonal contraception use or IUD
Study Location
Trio Fertility
Trio FertilityToronto, Ontario
Canada
Contact Study Team
Robert. F. Casper, Dr.
- Study Sponsored By
- Trio Fertility
- Participants Required
- More Information
- Study ID:
NCT06450301