Pharmacogenomics of Stimulant Treatment Response

Participation Requirements

• Sex:

  ALL

• Eligible Ages:

  6 to 17

Participation Criteria

Inclusion Criteria:

Patients will be eligible for participation if all the following are true.

* Aged 6 - 17 years
* Located in Alberta, Canada.
* Primary diagnosis of ADHD (all types).
* Initiating methylphenidate (excluding immediate release (IR) forms) treatment for the first time.

Exclusion Criteria:

Patients will be excluded from participation if any of the following are true.

* Co-occurring psychotic, bipolar or eating disorders.
* Significant risk of suicide.
* An intellectual disability, or diagnosis of autism spectrum disorder (ASD) or tics/Tourette disorders.
* Past 12-month high-risk alcohol or substance use defined as monthly or more frequent use.
* Psychotherapy or brain stimulation-based therapy initiated within 8 weeks of referral or plans to initiate/change these types of therapies during the study
* History of liver or bone marrow (hematopoietic cell) transplant as these events can result in ambiguous genomic results.