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Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2

Obesity | Chronic Kidney Disease

OK-TRANSPLANT 2 is a vanguard study for a large randomized, pragmatic, open-label trial.

We will randomize participants with obesity, high-risk CKD/dialysis who are hoping for lose weight for the purpose of kidney transplant. Subjects will either be enrolled on a virtual weight management program or continue their usual care.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

* Adults aged 18 years or older
* BMI \> 35 kg/m\^2
* \>10% risk of ESKD requiring renal replacement therapy over 2 years or receiving dialysis

Exclusion Criteria:

* Known contraindication to a GLP-1RA
* Type 1 diabetes
* Current use of more than the starting dose of semaglutide, liraglutide, or dulaglutide
* No access to semaglutide via drug coverage
* Absolute contraindication to kidney transplant
* Pregnant, breastfeeding or planning to become pregnant

Study Location

London Health Sciences Centre
London Health Sciences Centre
London, Ontario
Canada

Contact Study Team

Backup Contact

Louise Moist, MD

Primary Contact

Heather LaPier, BSc

[email protected]
519-646-6100
Backup Contact

Michael Chiu, MD

Study Sponsored By
Western University, Canada
Participants Required
More Information
Study ID: NCT06396416