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HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease

Huntington's Disease

HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high quality plasma sample collection matching the CSF collections, which will also be used to evaluate biomarkers and pathways of relevance to HD research and development.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    11 to 75

Participation Criteria

Inclusion Criteria:

* Age (18-75 years controls, early/late premanifest HD and incomplete penetrance HD, 21-75 years early/moderate/advanced manifest HD, ≥11 years juvenile HD)
* Enroll HD participant
* Capable of consenting or have a legal representative (parent/guardian for juveniles)
* Capable of complying with study procedures
* All participants other than family and community controls must have had a genetic test for HD

Exclusion Criteria:

* Drug trial within 30 days of any sampling visit
* Changes in medication (antidepressant, psychoactive, psychotropic or other medications or nutraceuticals used to treat HD within 30 days)
* Antiplatelet or anticoagulant therapy within 14 days
* Significant comorbidity
* Needle phobia, headache, spinal surgery / deformity
* Clotting or bruising disorder
* Screening blood test abnormalities \>10% outside normal range
* Drug / alcohol abuse
* Positive urine pregnancy test at any screening or sampling visit for females of childbearing potential
* Predictable non compliance or unwillingness
* Serious adverse event related to HDClarity study procedures or any lumbar puncture procedure performed for any reason in the previous 30 days

Study Location

Centre for Movement Disorders
Centre for Movement Disorders
Toronto, Ontario
Canada

Contact Study Team

North York General Hospital
North York General Hospital
Toronto, Ontario
Canada

Contact Study Team

Primary Contact

Rebecca Solmito

[email protected]
University of British Columbia, The Centre for Huntingtons Disease
University of British Columbia, The Centre for Huntingtons Disease
Vancouver, British Columbia
Canada

Contact Study Team

Primary Contact

Mike Adurogbangba

[email protected]
604-822-4872
The Ottawa Hospital
The Ottawa Hospital
Ottawa, Ontario
Canada

Contact Study Team

Primary Contact

Jane Ding

[email protected]
Study Sponsored By
University College, London
Participants Required
More Information
Study ID: NCT02855476