REDEFINE-HF

Participation Requirements

• Sex:

  Any

• Eligible Ages:

  18 and up

Participation Criteria

Inclusion Criteria:
1. Provide electronic or written informed consent
2. Age ≥18 years
3. Current hospitalization or recently discharged (within 10 days prior to screening) with heart failure
4. Heart failure signs and symptoms at the time of hospital admission
5. Imaging evidence of mildly reduced or preserved ejection fraction (40% or higher)
6. Elevated N-terminal pro B-type natriuretic peptide (NTproBNP) ≥1000 pg/mL
7. Treatment during the index hospitalization with at least 1 intravenous dose of a loop
diuretic.
Exclusion Criteria:
1. Treatment with an MRA within 30 days prior to randomization
2. eGFR <25 mL/min/1.73m² or serum/plasma potassium >5.0 mmol/L at screening
3. Acute MI, coronary revascularization, valve replacement/repair, or implantation of a
cardiac resynchronization therapy device within 30 days prior to randomization.
4. Prior heart transplant
5. Cardiomyopathy due to known acute inflammatory heart disease
6. Participation in another interventional clinical study