Application of High-dose Insulin Therapy to Improve Liver Function and Regeneration
Liver Dysfunction | Liver Regeneration | Liver Metastasis Colon CancerThe primary objective of this interventional study is determine if the future liver remnant can be optimized by improving liver function pre-operatively in patients who are scheduled for major hepatectomy. The main questions it aims to answer are:
1. Does high-dose insulin therapy improve liver function in the pre-operative setting?
2. What is the effect of high-dose insulin therapy on liver function and liver regeneration after a liver venous deprivation (LVD) procedure?
3. What is the relationship between volume hypertrophy and function in the regenerating liver? Participants will receive a 6-hour infusion of insulin and dextrose to maintain a hyperinsulinemic-normoglycemic state in the weeks prior to planned liver surgery to assess its effect on liver function measured by 99m-Tc-Mebrofenin hepatobiliary scintigraphy.
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Conditions de participation
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Sexe:
ALL -
Âges admissibles:
18 and up
Critères de participation
Inclusion Criteria:
* Age \> 18 years old
* Candidate for major liver resection
* Resectable colorectal liver metastasis
Exclusion Criteria:
* Inability to give consent
* Type 1 diabetes mellitus
* Uncontrolled blood glucose levels (fasting level \> 10 mmol/L)
* Unresectable colorectal liver metastasis
* Extrahepatic metastatic disease that is unresectable
Lieu de l'étude
McGill Univeristy Health Centre
McGill Univeristy Health CentreMontreal, Quebec
Canada
Contactez l'équipe d'étude
- Étude parrainée par
- McGill University Health Centre/Research Institute of the McGill University Health Centre
- Participants recherchés
- Plus d'informations
- ID de l'étude:
NCT06126419