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Sodium Deposition in Soft Tissues of Patients with Kidney Disease

Haemodialysis Complication

Sodium (Na+) hemostasis is abnormal in CKD patients, and this element can be deposited in the skin, muscle, and skeleton - to cope with long term sodium loading. It is known that sodium stored in this non-osmotically active way, is profoundly inflammatory. Furthermore, inflammation has been associated with several uremic symptoms. The investigators will use novel Na+ MRI imaging to examine the Na+ deposition in the skin, muscle, and skeleton of five groups:1) chronic in-center hemodialysis patients, 2) chronic peritoneal dialysis patients, 3) adult and paediatric patients with CKD stage 1-5 and 4) heart failure patients with and without renal dysfunction 5) sex and age-matched healthy adult and paediatric controls. Additionally, they will investigate the association between sodium deposition in these tissues with uremic symptomatology and biochemical markers of metabolism.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    6 and up

Participation Criteria

Inclusion Criteria:

* Age greater than or equal to 6 years
* For patients on maintenance hemodialysis or peritoneal dialysis: more than 3 months duration of therapy
* For patients with CKD stage 1-5: CKD stage 1-5 and no indications to start dialysis
* For heart failure patients: with or without renal dysfunction
* For healthy controls: lack of kidney disease, heart failure, liver cirrhosis, and peripheral edema

For subsequent visits (must meet 1 of the below indicators):

* Change in dialysis prescription
* Change in renal replacement therapy modality
* Change in medication
* Parathyroidectomy
* Intervention added to or removed from dialysis (i.e. such as but not limited exercise, cooling, and ischemic preconditioning)

Exclusion Criteria:

* Pregnant, breastfeeding or intending pregnancy
* Unable to give consent or understand written information
* Contraindication to MRI study

Study Location

LHSC Regional Renal Care Program
LHSC Regional Renal Care Program
London, Ontario
Canada

Contact Study Team

Backup Contact

Jean Theberge, PhD

Backup Contact

Guido Filler, MD

Primary Contact

Christopher W McIntyre, MD, PhD

[email protected]
519-685-8500
Backup Contact

Timothy Scholl, PhD

Backup Contact

Alireza Akbari, PhD

Study Sponsored By
London Health Sciences Centre Research Institute and Lawson Research Institute of St. Joseph's
Participants Required
More Information
Study ID: NCT03004547