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Dietary Fish Oil Intervention in Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Syndrome | Lipid Metabolism Disorders

The primary objective in this proposed study is to determine the effect of dietary fish oil supplementation compared to standard care metformin treatment, and fish oil in combination with metformin on plasma lipids and apoB-remnant lipoprotein metabolism in overweight-obese young women with PCOS.

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Conditions de participation

  • Sexe:

    FEMALE

  • Âges admissibles:

    18 to 30

Critères de participation

Inclusion Criteria:

* Female
* Age at time of enrollment \> 18 to \<30 years
* Diagnosis of PCOS: clinical and/or biochemical hyperandrogenemia and menstrual dysfunction and the exclusion of other disorders.
* Overweight-obese (BMI \>25 kg/m2) high-risk metabolically-resistant young women.
* Elevated fasting plasma TG (\>150 mg/dL) and apoB48-remnant cholesterol lipoproteins (\>20 ug/ml).
* Impaired insulin sensitivity (glucose 100-125 mg/dL and/or insulin \>15 (uM/ml); and
* May be diagnosed with T2D (blood glucose \>126 mg/dL).

Exclusion Criteria:

* Pregnancy
* Lactating women
* Recent illness that the investigator determines to pose a potential risk for the participant
* Concomitant medications that influence metabolism (e.g. statins)
* Excessive alcohol consumption, as determined by the investigator.

Lieu de l'étude

2-004 Li Ka Shing Centre, UofA
2-004 Li Ka Shing Centre, UofA
Edmonton, Alberta
Canada

Contactez l'équipe d'étude

Primary Contact

Stara Morning

[email protected]
7802385111
9-111 Endocrinology Department, UofA Hospital
9-111 Endocrinology Department, UofA Hospital
Edmonton, Alberta
Canada

Contactez l'équipe d'étude

Primary Contact

Mahua Ghosh, MD

[email protected]
780 492 6444
Étude parrainée par
University of Alberta
Participants recherchés
Plus d'informations
ID de l'étude: NCT04116203