Molecular Analysis of Diabetic Kidney Disease Biopsies
Diabetic Nephropathies | Kidney Disease, ChronicDespite decades of research, the pathogenesis of human diabetic kidney disease remains largely unclear. Our goal is to use archived human kidney biopsy tissue from patients with and with diabetic nephropathy to identify new molecules that drive and/or protect against disease progression. We will use RNA sequencing to identify transcriptomic changes that associate with histologic and functional outcomes.
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Conditions de participation
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Sexe:
ALL -
Âges admissibles:
18 and up
Critères de participation
Inclusion Criteria (diabetic kidney disease cases):
* history of type 1 or type 2 diabetes
* at least 1 archived native kidney biopsy that demonstrates either pure diabetic kidney disease or features of non-specific vascular disease, including glomerulosclerosis, non-inflammatory vascular disease,
* sufficient remaining archived kidney biopsy tissue for RNA sequencing (100 um thick tissue section) and histologic analysis (PAS and Masson Trichrome staining)
Exclusion Criteria (diabetic kidney disease cases):
* less than 3 eGFR values post-biopsy
* latest recorded eGFR values less than 6 months post-biopsy
Inclusion Criteria (healthy controls):
- at least 1 native kidney disease biopsy with no diagnostic abnormality
Lieu de l'étude
University of Ottawa
University of OttawaOttawa, Ontario
Canada
Contactez l'équipe d'étude
Kevin Burns, MD
University of Manitoba
University of ManitobaWinnipeg, Manitoba
Canada
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Claudio Rigatto, MD
St. Michael's Hospital
St. Michael's HospitalToronto, Ontario
Canada
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University of British Columbia
University of British ColumbiaVancouver, British Columbia
Canada
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Sean Barbour, MD
- Étude parrainée par
- Unity Health Toronto
- Participants recherchés
- Plus d'informations
- ID de l'étude:
NCT04029402