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Pathophysiology of post-traumatic headache: What are we missing?

Migraine | Headache | MRI | Concussion Symptoms and Signs

This study aims to learn more about the basis of chronic post-traumatic headache following concussion. Chronic post-traumatic headache is in many ways similar to chronic migraine. In this study, we will compare a variety of measures from individuals with chronic post-traumatic headache, individuals with chronic migraine and healthy controls. Participants will complete questionnaires, undergo an MRI scan, and have a blood draw. A better understanding of how chronic post-traumatic headache and chronic migraine differ (and are similar) will inform more effective treatments.

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Participation Requirements

  • Sex:

    Male, Female, Intersex

  • Eligible Ages:

    25 to 65

Participation Criteria

Inclusion Criteria:
Chronic post-traumatic headache
1) History of at least 1 physician-diagnosed concussion
2) Diagnosis of post-traumatic headache

Chronic Migraine
1) Diagnosis of chronic migraine

Healthy controls
1) No history of head injury
2) No history of headache or chronic pain disorder
Exclusion Criteria:
1) Contraindications to MRI imaging
2) Major medical conditions (i.e., liver failure, stroke, epilepsy)
3) Illicit drug use in the past 6 months (not including marijuana)
4) Some mental health or neurological diagnoses (i.e., psychosis, Autism)
5) Autoimmune conditions (i.e. Crohn's disease, rheumatoid arthritis)

Study Location

University of Calgary
University of Calgary
Calgary, Alberta
Canada

Contact Study Team

Study Sponsored By
University of Calgary
Participants Required
More Information
Study ID: REB24-1279