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Crohn's Disease - Inflammation and Microbial Proteolytic Activity

Crohn's Disease of Both Small and Large Intestine

This study postulates that altered microbiota associated with areas of mucosal inflammation in CD, can be characterized by an increased proteolytic profile. This is clinically important as it may be possible to modulate the proteolytic activity of the CD-associated bacteria by using other bacteria that produce protease inhibitors, such as serpins.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 to 70

Critères de participation

Inclusion Criteria:

* Be aged between 18 - 70 years old
* Have a confirmed diagnosis of Crohn's disease
* Have a clinical indication for standard, white light colonoscopy to assess disease activity and extent

Exclusion Criteria:

* Inability to provide written informed consent
* Presence of serious life-threatening co-morbidities
* Evidence of toxic megacolon, jaundice, cirrhosis, renal dysfunction, acute GI bleeding
* History of difficult colonoscopy, strictures or extensive diverticulosis
* Antibiotics in the last month
* Probiotics in the last week

Lieu de l'étude

McMaster University
McMaster University
Hamilton, Ontario
Canada

Contactez l'équipe d'étude

Backup Contact

Elena F Verdu, MD

Backup Contact

Janet Szeto

[email protected]
905-521-2100
Primary Contact

David Armstrong, MD

[email protected]
905 521 2100
Étude parrainée par
McMaster University
Participants recherchés
Plus d'informations
ID de l'étude: NCT06503081