Xenon-129 Magnetic Resonance Imaging of Healthy Subjects: Hardware and Software Development and Reproducibility
Healthy VolunteersHealthy volunteers aged 18-85 will undergo hyperpolarized 129-Xe MRI and pulmonary function testing for the development of tools to assess image signal to noise and reproducibility of spin-density and diffusion-weighted imaging.
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Conditions de participation
-
Sexe:
ALL -
Âges admissibles:
18 to 85
Critères de participation
Inclusion Criteria:
* able to perform a breath hold for up to 16 sec
* BMI between 18 and 40
* stable health on the basis of medical history
* smoking history \< 1 pack/year
Exclusion Criteria:
Patient is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand the written material.
* Subject has a daytime room air oxygen saturation \<90% while lying supine.
* Patient is unable to perform spirometry or plethysmography maneuvers
* Patient is pregnant
* In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia.
* Subject has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants.)
Lieu de l'étude
Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
Robarts Research Institute; The University of Western Ontario; London Health Sciences CentreLondon, Ontario
Canada
Contactez l'équipe d'étude
- Étude parrainée par
- Western University, Canada
- Participants recherchés
- Plus d'informations
- ID de l'étude:
NCT02484885