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Fluids in Septic Shock (FISSH)

Sepsis, Septic Shock

Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world. Given uncertainty about the impact of lower chloride versus higher chloride solutions on mortality, it is unlikely that clinical practice will change without new and direct randomized controlled trial (RCT) evidence. Editorials published in leading critical care journals have called for RCT's to address this important clinical question. This trial will directly compare low chloride versus normal chloride for resuscitation in septic shock on patient-important outcomes such as mortality and AKI.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    16 and up

Critères de participation

Inclusion Criteria:

* patients 16 years or greater who meet all of the following:
* require fluid resuscitation for refractory hypotension (systolic blood pressure \<90 mmHg or mean arterial blood pressure\<65 mmHg after 1 Litre bolus over 1 hour or less or organ hypo-perfusion (serum lactate \>4 mmol/L)
* have a clinical suspicion of infection
* are within 6 hours of hospital admission or critical care response team consultation
* are anticipated to require ICU admission

Exclusion Criteria:

* intracranial bleed or intracranial hypertension during the index hospital admission
* 10% of body surface area acute burn injury
* bleeding/hemorrhage as likely cause of hypotension
* a lack of commitment to life support
* have previously enrolled in FISSH, or a confounding trial (e.g. a trial examining the effect of other intravenous fluids in septic shock patients)
* been transferred from another hospital or facility \>6 hours since presentation to first hospital
* pre-established end stage renal disease (ESRD) or are receiving hemodialysis (intermittent or continuous) at time of enrolment, or
* been admitted to ICU directly from the operating room or post anaesthetic care unit

Lieu de l'étude

University of Calgary - Foothills Medical Centre
University of Calgary - Foothills Medical Centre
Calgary, Alberta
Canada

Contactez l'équipe d'étude

Primary Contact

Lois Hagan, CRA

[email protected]
(403)-944-2160
Victoria General
Victoria General
Halifax, Nova Scotia
Canada

Contactez l'équipe d'étude

Primary Contact

Linda Hastie, RN, BHScN

[email protected]
902-499-9225
Hamilton General Hospital
Hamilton General Hospital
Hamilton, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Lori Hand, RRT

[email protected]
Lakeridge Health
Lakeridge Health
Oshawa, Ontario
Canada

Contactez l'équipe d'étude

Backup Contact

Sarah Dulmage, ScH

[email protected]
Primary Contact

Barbara Flynn, RN BScN

[email protected]
Sunnybrook Health Sciences Centre
Sunnybrook Health Sciences Centre
Toronto, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Nicole Marinoff, RN, CCRP

[email protected]
Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec (CIUSSS MCQ)
Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec (CIUSSS MCQ)
Trois-Rivières, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Alice Lefebvre, RC

[email protected]
819 697-3333
Halifax Infirmary
Halifax Infirmary
Halifax, Nova Scotia
Canada

Contactez l'équipe d'étude

Primary Contact

Linda Hasties, RN, BHScN

[email protected]
902-499-9225
Juravinski Hospital-Hamilton Health Sciences
Juravinski Hospital-Hamilton Health Sciences
Hamilton, Ontario
Canada

Contactez l'équipe d'étude

Backup Contact

Tina Millen, RRT

[email protected]
905-719-6133
Primary Contact

Bram Rochwerg, MSc,MD,FRCPC

[email protected]
905-521-2100
London Health Sciences - University Hospital
London Health Sciences - University Hospital
London, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Tracey C Bentall

[email protected]
Backup Contact

Eileen Campbell

[email protected]
Mount Sinai Hospital
Mount Sinai Hospital
Toronto, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Sumesh Shah, CCRP

[email protected]
416-586-4800
Centre de recherche du CIUSSS de l'Estrie - CHUS de Sherbrooke
Centre de recherche du CIUSSS de l'Estrie - CHUS de Sherbrooke
Sherbrooke, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Marie-Pier Bouchard, RA

[email protected]
University of Calgary - Rockyview General Hospital
University of Calgary - Rockyview General Hospital
Calgary, Alberta
Canada

Contactez l'équipe d'étude

Primary Contact

Lois Hagan, CRA

[email protected]
(403)-944-2160
Brantford General Hospital
Brantford General Hospital
Brantford, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

William Dechert, MSc

[email protected]
519-752-7871
Kingston General Hospital
Kingston General Hospital
Kingston, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Tracy Boyd, CCRC

[email protected]
613-549-6666
Niagara Health, St Catharines Site
Niagara Health, St Catharines Site
St Catharines, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Lisa Patterson, RC

[email protected]
Centre intégré Universitaire de santé et de services sociaux du Nord de l'île de Montréal
Centre intégré Universitaire de santé et de services sociaux du Nord de l'île de Montréal
Montreal, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Virginie Williams, PhD

[email protected]
514 338 2222
Grey Nuns Community Hospital
Grey Nuns Community Hospital
Edmonton, Alberta
Canada

Contactez l'équipe d'étude

Primary Contact

Anushka Jayasekara, RC

[email protected]
St Joseph's Healthcare
St Joseph's Healthcare
Hamilton, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

France Clarke, RRT

[email protected]
905-522-1155
London Health Sciences Centre - Victoria Hospital
London Health Sciences Centre - Victoria Hospital
London, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Eileen Campbell, RN

[email protected]
519-685-8500
Unity Health (St. Michael's Hospital)
Unity Health (St. Michael's Hospital)
Toronto, Ontario
Canada

Contactez l'équipe d'étude

Primary Contact

Marlene Santos, MD, ACRP

[email protected]
416-864-6060
Centre Hospitalier de l'Universite de Montreal (CHUM)
Centre Hospitalier de l'Universite de Montreal (CHUM)
Montréal, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Andrea Gagnon-Hamelin

[email protected]
Étude parrainée par
McMaster University
Participants recherchés
Plus d'informations
ID de l'étude: NCT03677102