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Salbutamol Use in Ozone Air Pollution by People With Asthma and/or Exercise Induced Bronchoconstriction (EIB)

Asthma and/or Exercise Induced Bronchoconstriction | Ozone Air Pollution

Salbutamol use is increased in areas with high levels of ozone pollution and the potential consequences of this are not well known. The purpose of this study is to examine the effect of salbutamol on lung function and inflammation in people with asthma and/or EIB exercising in ozone air pollution. To examine this, we are planning a randomized cross over trial where people with asthma and/or EIB complete sub maximal exercise in four conditions on four separate days. The four condition are: ozone + salbutamol, filtered air + salbutamol, ozone + placebo medication, and filtered air + placebo medication.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 to 50

Participation Criteria

Inclusion Criteria:

* Have asthma and/or EIB
* Able to perform maximal exercise
* Able to communicate sufficiently using the English language

Exclusion Criteria:

* Allergic to salbutamol (also known as Ventolin)
* Pregnant or potentially pregnant
* Have a history of smoking
* Had an upper respiratory tract infection within the last 4 weeks
* Have a chronic respiratory disease other than asthma or EIB

Study Location

Environmental Physiology Laboratory
Environmental Physiology Laboratory
Vancouver, British Columbia
Canada

Contact Study Team

Primary Contact

Michael Koehle, MD, PhD

[email protected]
604 788 7268
Study Sponsored By
University of British Columbia
Participants Required
More Information
Study ID: NCT05087693