STICH3C
The purpose of this study is to evaluate and compare the effectiveness of percutaneous coronary intervention (PCI) against coronary artery bypass grafting (CABG) in patients with multivessel coronary artery disease (CAD) and ischemic left ventricular dysfunction (iLVSD).
Both procedures are standard of care for patients with multivessel CAD and iLVSD. It is unclear whether PCI or CABG result in better, long-term health outcomes. The purpose of this study is to determine if one is better than the other.
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Conditions de participation
-
Sexe:
Any -
Âges admissibles:
19 and up
Critères de participation
Inclusion Criteria:
1. Age greater than 18 years of age (adult only study)
2. Left ventricular ejection fraction (LVEF) </-40% quantified within 2 months of randomization.
3. Prognostically important multivessel coronary artery disease (triple vessel CAD or double vessel disease including the left main artery.
4. The institutional Heart Team agrees that guideline-directed medical therapy (GDMT) has been initiated for >/- 1 month in prevalent and newly diagnosed cases.
5. Signed informed consent.
Exclusion Criteria:
1. Decompensated heart failure requiring medical support less than 48 hours prior to randomization.
2. Recent (<4 weeks) heart attack.
3. Severe valvular disease requiring surgical repair or replacement.
4. Planned major concomitant surgical procedures
5. Prior PCI within the past 12 months.
6. Prior cardiac surgery.
7. Prohibitive bleeding risk mandating avoidance of dual antiplatelet therapy.
8. Circumstances likely to lead to poor treatment adherence.
9. Severe end-organ dysfunction that reduces life expectancy to <5 years.
10. Current pregnancy.
11. Patient not amenable to both CABG or PCI according to the Heart Team.
Lieu de l'étude
University of Alberta
University of AlbertaEdmonton, Alberta
Canada
Contactez l'équipe d'étude
- Étude parrainée par
- University of Alberta
- Participants recherchés
- Plus d'informations
- ID de l'étude:
Pro00127401