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Effect of Hyperandrogenism on IVF Outcomes in PCOS Patients

PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries

Ovulatory dysfunction affects 18 to 25% of infertile women, the most common identifiable condition is polycystic ovarian syndrome (PCOS). The most frequent symptoms of PCOS are oligo-anovulation, hyperandrogenism and polycystic ovary appearance.

Hyperandrogenism is the main contributor that affects oocyte and embryo quality and decreases the success rates in PCOS patients undergoing IVF treatments.

The aim of this study is to determine the effect of hyperandrogenism as an independent factor on IVF success rates and oocyte/embryo quality in PCOS patients undergoing IVF.

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Conditions de participation

  • Sexe:

    FEMALE

  • Âges admissibles:

    18 to 39

Critères de participation

Inclusion Criteria:

* Women between ages of 18 - 39 inclusively
* ≥15 oocytes collected on the day of oocyte retrieval and/or anti-mullerian hormone (AMH) ≥ 4.0 ng/ml in the participant's medical chart in the last 24 months

Exclusion Criteria:

* Male factor necessitating testicular sperm aspiration (TESA), testicular sperm extraction (TESE) or micro-TESE
* Fertility preservation
* Recurrent pregnancy losses (RPL) (defined as 2 or more failed clinical pregnancies as documented by ultrasonography or histopathologic examination,or 3 or more failed pregnancies before 14 weeks of gestation)
* Oocyte donation
* Medical diagnosis of non classic congenital adrenal hyperplasia diagnosed based on 17 hydroxyprogesterone level

Lieu de l'étude

Clinique Ovo
Clinique Ovo
Montreal, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Marya Far, MSc

[email protected]
5147982000
Étude parrainée par
Clinique Ovo
Participants recherchés
Plus d'informations
ID de l'étude: NCT05555680