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eMESH Struct. 2022-23

Septic Shock | Chronic Heart Failure

A flexible energy metabolism matched with the contractile needs of the muscle is essential to a normal heart. Loss of metabolic flexibility and cardiac systolic efficiency coexist in Sepsis-induced Myocardial Dysfunction (SIMD), a phenomenon attributed to mitochondrial dysfunction and mishandling of energy substrates. Cardiac positron emission tomography (PET) could allow to quantify non invasively the selection of energy substrates by the hearts in sepsis and will be associated in parallel with functional status (ultrasound cardiography), injury biomarkers, apelinergic and metabolomic blood profiles. Comparisons will be performed between septic and acute on chronic heart failures, with or without systolic dysfunction.

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Participation Requirements

  • Sex:

    ALL

  • Eligible Ages:

    18 and up

Participation Criteria

Inclusion Criteria:

* Patients hospitalized in intensive care unit and coronary unit of the Sherbrooke hospital/CHUS.
* Accepts healthy volunteers: 4 to 6 age- and sex-matched HV will be recruited and imaged at the end of the inclusion window for the assessment of cardiac energy tracer's uptake and as ref. controls.

Exclusion Criteria:

* Pediatric patients
* Albumin allergy
* Moribund patients
* Patients too much unstable for the imaging procedure (clinical judgment)
* Unavailable tracers, staff, PET scan in a maximum delay of 72 hours

Study Location

CHUS
CHUS
Sherbrooke, Quebec
Canada

Contact Study Team

Study Sponsored By
Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Participants Required
More Information
Study ID: NCT05202938