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Transanal Irrigation for the Management of LARS

Rectal Cancer | Low Anterior Resection Syndrome

This study aims to evaluate the impact of Transanal irrigation (TAI) on the quality of life and low anterior resection symptoms (LARS) in Canadian rectal cancer survivors living with minor to major LARS. It proposes to teach TAI through a novel online platform and to provide virtual nursing support for the participants. To our knowledge, this is the first North American based and largest randomized control trial on the use of TAI for patients with LARS. This will also be the first study to teach and support patients through the TAI process using a virtual platform. While TAI has been demonstrated to reduce LARS scores and increased QoL in patients with significant LARS, its feasibility and acceptance for Canadian patients remains uncertain. Furthermore despite the existing studies, the rate of TAI seems to be low in North America. The hypothesis is that TAI, taught and supported through an online portal dedicated to LARS patients, will positively impact QoL and improve LARS symptoms. The results of this trial may allow TAI to become part of the standard armamentarium that clinicians offer patients for LARS management, with the presence of online nursing support and guidance to facilitate this practice.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 and up

Critères de participation

Inclusion Criteria:

* Low anterior resection by a laparoscopic, robotic, transanal total mesorectal excision, or open approach with (or without) creation of a diverting loop ileostomy for the treatment of rectal cancer, advanced adenoma or dysplasia And
* have had their ileostomy closed (if applicable) And
* completed treatment at least 6 months ago (including ileostomy closure) And
* LARS score \> 20 points

Exclusion Criteria:

* Inability to provide informed consent, including fluency in English or French language
* unable to access the internet,
* presence of an ostomy,
* no active or ongoing treatment
* anastomotic stricture, sinus or any other ongoing anastomotic complications.

Lieu de l'étude

Jewish General Hospital
Jewish General Hospital
Montreal, Quebec
Canada

Contactez l'équipe d'étude

Primary Contact

Marylise Boutros, MD, MSc, FRCSC, FACS. FABCRS

[email protected]
514-340-8222
McGill University Health Centre
McGill University Health Centre
Montréal, Quebec
Canada

Contactez l'équipe d'étude

Backup Contact

Sender Liberman

Primary Contact

Jessica Holland, MD

[email protected]
Étude parrainée par
Jewish General Hospital
Participants recherchés
Plus d'informations
ID de l'étude: NCT05007015