POTS Adrenergic Ab (CIHR Aims #1&2)

Participation Requirements

• Sex:

  ALL

• Eligible Ages:

  18 to 60

Participation Criteria

Inclusion Criteria:

* Patients who have been previously diagnosed with POTS
* Control subjects (patients not diagnosed with POTS)
* Age between 18 - 60 years
* Males and Females (Give that \>80% of POTS patients are female, we will attempt to enroll a similar percentage of female control subjects)
* Able and willing to provide consent

Exclusion Criteria:

* Smokers
* Overt cause for postural tachycardia, i.e., acute dehydration
* Significant cardiovascular, pulmonary, hepatic, or hematological disease by history or prior testing
* Highly trained athletes
* Subjects with somatization or severe anxiety symptoms will be excluded
* Use of drospirenone (a spironolactone analogue) containing oral contraceptive agent
* Hypertension defined as supine resting BP\>145/95 mmHg off medications or needing antihypertensive medication
* Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule
* Unable to give informed consent