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Gut Microbiota in Chronic GI Diseases

Microbiota

The study involves characterizing the microbiota of patients with IBS, functional diarrhea, IBD, severe motility disorders and celiac disease.

This will be complemented by a translational phase of human-mouse hybrid experiments in which germ-free mice will be colonized with feces from these patients with different GI disease and non-disease controls and we will compare symptoms, microbiota composition and histological changes in the gut and in the brain of the mice.

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Conditions de participation

  • Sexe:

    ALL

  • Âges admissibles:

    18 to 75

Critères de participation

Inclusion Criteria:

* Diagnosis of IBD, active celiac disease (aTTG positive + endoscopic view and histological findings compatible), IBS (Rome IV criteria or physician diagnosis) severe motility disorders (severe constipation, severe functional dyspepsia) gluten sensitivity (IBS diarrhea predominant with positive anti gliadin antibodies and negative aTTG), functional diarrhea (Rome IV criteria), anal fissure and/or fistula or non-disease control individual or 1st degree family member of celiac patient.
* Willingness to participate
* Signed Informed Consent

Exclusion Criteria:

* Antibiotics in the last month
* Probiotics in the previous month

Lieu de l'étude

McMaster University
McMaster University
Hamilton, Ontario
Canada

Contactez l'équipe d'étude

Backup Contact

Andrea Nardelli, MD

[email protected]
905-521-2100
Primary Contact

Gaston H Rueda, MD

[email protected]
905 521-2100
Étude parrainée par
McMaster University
Participants recherchés
Plus d'informations
ID de l'étude: NCT06532110